On mast cells in the choroid plexus of the axolotl (Ambystoma Mex.)

Kappers, J. Ariëns; Kate, Ief B. ten; Bruyn, H. J. de

doi:10.1007/bf00398650

Cited by 22 publications

(9 citation statements)

References 25 publications

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“…These results (compare Fig. 6L and 6K) suggest that when Notch1-ICD is expressed, normally non-mitotic hCPe cells (Kappers et al, 1958;Knudsen, 1964;Li et al, 2002;Sturrock, 1979) proliferate.…”

Section: Research Articlementioning

confidence: 78%

Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus

Hunter

Dymecki

2007

Development

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Both hindbrain roof plate epithelium (hRPe) and hindbrain choroid plexus epithelium (hCPe) produce morphogens and growth factors essential for proper hindbrain development. Despite their importance, little is known about how these essential structures develop. Recent genetic fate maps indicate that hRPe and hCPe descend from the same pool of dorsal neuroectodermal progenitor cells of the rhombic lip. A linear developmental progression has been assumed, with the rhombic lip producing non-mitotic hRPe, and seemingly uniform hRPe transforming into hCPe. Here, we show that hRPe is not uniform but rather comprises three spatiotemporal fields, which differ in organization, proliferative state, order of emergence from the rhombic lip, and molecular profile of either the constituent hRPe cells themselves and/or their parental progenitors. Only two fields contribute to hCPe. We also present evidence for an hCPe contribution directly by the rhombic lip at late embryonic stages when hRPe is no longer present; indeed, the production interval for hCPe by the rhombic lip is surprisingly extensive. Further, we show that the hCPe lineage appears to be unique among the varied rhombic lip-derived lineages in its proliferative response to constitutively active Notch1 signaling. Collectively, these findings provide a new platform for investigating hRPe and hCPe as neural organizing centers and provide support for the model that they are themselves patterned structures that might be capable of influencing neural development along multiple spatial and temporal axes.

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Section: Research Articlementioning

confidence: 78%

Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus

Hunter

Dymecki

2007

Development

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“…The post differentiated development of the choroid plexus cells themselves has proved a more difficult beast to investigate. Much study using cell division markers have shown no examples of choroid plexus epithelial cells undergoing division to produce additional plexus epithelium, while in contrast, many mitotic figures have been described in the nearby neuroependyma (Zand, 1930; Kappers et al, 1958). An aside should be noted however that there are examples of a proliferative choroid plexus giving rise to neuronal and glial lineage cells (Itokazu et al, 2006; Bolos et al, 2013).…”

Section: Normal Developmentmentioning

confidence: 99%

Development of the choroid plexus and blood-CSF barrier

2015

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Well-known as one of the main sources of cerebrospinal fluid (CSF), the choroid plexuses have been, and still remain, a relatively understudied tissue in neuroscience. The choroid plexus and CSF (along with the blood-brain barrier proper) are recognized to provide a robust protective effort for the brain: a physical barrier to impede entrance of toxic metabolites to the brain; a “biochemical” barrier that facilitates removal of moieties that circumvent this physical barrier; and buoyant physical protection by CSF itself. In addition, the choroid plexus-CSF system has been shown to be integral for normal brain development, central nervous system (CNS) homeostasis, and repair after disease and trauma. It has been suggested to provide a stem-cell like repository for neuronal and astrocyte glial cell progenitors. By far, the most widely recognized choroid plexus role is as the site of the blood-CSF barrier, controller of the internal CNS microenvironment. Mechanisms involved combine structural diffusion restraint from tight junctions between plexus epithelial cells (physical barrier) and specific exchange mechanisms across the interface (enzymatic barrier). The current hypothesis states that early in development this interface is functional and more specific than in the adult, with differences historically termed as “immaturity” actually correctly reflecting developmental specialization. The advanced knowledge of the choroid plexus-CSF system proves itself imperative to understand a range of neurological diseases, from those caused by plexus or CSF drainage dysfunction (e.g., hydrocephalus) to more complicated late-stage diseases (e.g., Alzheimer's) and failure of CNS regeneration. This review will focus on choroid plexus development, outlining how early specializations may be exploited clinically.

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“…The lymphoblastic population is likely to contain not only B and T lymphocytes, but monocytes and HPCs depending on tissue source. The mature myeloid cell population contained Alcian blue-positive mast cells, a-naphthyl butyrate esterase-expressing macrophages, and myeloperoxidase-positive neutrophils 18,[29][30][31][32][33] ( Figure 2D). …”

Section: Cfu (Cfu-e) (mentioning

confidence: 99%