On markers of early detection of endometriosis-associated ovarian tumours

Davydov, A.I.; Mikhaleva, L.M.; Patsap, Olga I.

doi:10.20953/1726-1678-2019-4-133-137

Cited by 1 publication

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“… 16 Overtime, endometrioid disorders may analogously obtain genetic mutations, which are commonly associated with cancer, such as those caused by oxidative stress, replicative aging, or other, yet unidentified, factors. 17 To date, endometriosis-related epithelial mutations have not been proven to increase the cancer risk of their carriers. However, it is clear that an endometrioid transformation exists in neoplastic lesions, which occur in 0.7–1.6% patients.…”

Section: Resultsmentioning

confidence: 99%

Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature

Михалева¹,

Radzinsky²,

Оразов³

et al. 2021

IJWH

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Objective To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. Methods A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. A multilingual search was performed. Results Several mechanisms underline the pathophysiological pathways for endometriosis development. Epigenetic mutations, external and internal influences, and chronic conditions have a significant impact on endometriosis development, survival and regulation. Several historically valid theories on endometriosis development were discussed, as well as updated findings. Conclusion Despite recent advances, fundamental problems in understanding endometriosis remain unresolved. The identification of unknown circulating epithelial progenitors or stem cells that are responsible for epithelial growth in both the endometrium and endometriotic foci seems to be the next step in solving these questions.

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Section: Resultsmentioning

confidence: 99%