The decentralized control of multi-input, multioutput (MIMO) industrial processes has always been an interesting topic for researchers. In this article, an online decoupling scheme of MIMO processes using an extremum-seeking approach is proposed. By applying the developed method, at first, the system's loop interactions are estimated in real-time using phasor extremum seeking, and then, a pre-compensator matrix is calculated and augmented to the process by minimizing the loop interactions. The presented online decoupling approach is a model-less method, and only the plant's inputs and outputs are analyzed to provide the decentralized control protocol. Numerical results provide the effectiveness of the developed method for a two-input, two-output (TITO) control system.