On-line Measurement and Control of Penicillin V Production

Modelling and adaptive control of fed‐batch penicillin fermentation

“…Although, as discussed earlier, a number of authors have investigated the application of modem control techniques to bioreactor control, the recent work of Dochain and Bastin (1984), Takamatsu et al (1985), Poulisse (1985), Frueh et al (1985), Dekkers and Voetter (1985), Montgomery et al (1985) and Verbruggen et al (1985) are most relevant to the adaptive control studies described here. Almost all the stud- ies are concerned with yeast fermentations with only Frueh et al (1985) investigating penicillin fermentation.…”

“…Although, as discussed earlier, a number of authors have investigated the application of modem control techniques to bioreactor control, the recent work of Dochain and Bastin (1984), Takamatsu et al (1985), Poulisse (1985), Frueh et al (1985), Dekkers and Voetter (1985), Montgomery et al (1985) and Verbruggen et al (1985) are most relevant to the adaptive control studies described here. Almost all the stud- ies are concerned with yeast fermentations with only Frueh et al (1985) investigating penicillin fermentation. Dochain and Bastin (1984) initially tried to use a minimum variance control policy before adopting a self-tuning GMV control law of the Clarke and Gawthrop (1979) type; whilst Poulisse (1985), Dekkers and Voetter (1985) and Montgomery et al (1985) utilize LQ and LQG methods of adaptive control.…”

“…Dochain and Bastin (1984) initially tried to use a minimum variance control policy before adopting a self-tuning GMV control law of the Clarke and Gawthrop (1979) type; whilst Poulisse (1985), Dekkers and Voetter (1985) and Montgomery et al (1985) utilize LQ and LQG methods of adaptive control. Frueh et al (1985) uses a minimum variance type of selftuning control law with a cascaded PI compensator, whilst Verbruggen et al (1985) applied a pole placement selftuning controller with an outer loop integrator. Almost without exception, the models used for control law derivation have been of the CARMA form leading to the problem of including integral action in the resulting control law.…”