On-line combination of aqueous-sample preparation and capillary gas chromatography

Vreuls, J. J.; Louter, A. J. H.; Brinkman, U.A.Th.

doi:10.1016/s0021-9673(99)00432-x

Cited by 55 publications

(21 citation statements)

References 166 publications

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“…The extraneous peaks from PDMS were also considerable. The suitability of this phase for thermal desorption has been claimed [29], though it was also noticed that disturbing siloxane breakdown products could also occur [17,18]. Pre-washing of about 5 mg PDMS with 750 ixL ethyl acetate and subsequent pre-heating at 300 ~ for 24 hours decreased the background level, but severe interferences remained visible, even with mass spectrometric detection in the SIM mode.…”

Section: Selection Of the Stationary Phasementioning

confidence: 99%

Solid-phase extraction—Thermal desorption—Gas chromatography with mass selective detection for the determination of drugs in urine

et al. 2003

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Key WordsGas chromatography -mass spectrometry Solid-phase extraction-thermal desorption Prog ra m m ed-te m pe rat u re va po rise r Lidocaine and diazepam in urine SummarySolid-phase extraction (SPE) was combined with thermal clesorption (TD) and gas chromatographic (GC) analysis to determine drugs in urine. The extraction was performed inside a fritted GC liner using about 5 mg TENAX that was inserted into the liner on top of the frit. After extraction, the hner was placed into the injector of the GC and the analytes were thermally clesorbed by using a programmed-temperature vaporiser. Several sorbent materials were investigated for the applicability of SPETD-GC analysis. TENAX proved to be the most suitable sorbent, since hardly any interferences were observed and acceptable absolute recoveries (73 and 74%) were obtained for liclocaine and cliazepam. A mass selective detector (MSD) in the selected ion monitoring mode allowed detection of hclocaine and cliazepam clown to 0.5 ng 9 mL 1 using 50 I~L urine. The use of only5 mg of extraction material allowed rapid extraction, while a 10 m GC column provided a fast chromatographic system. As a result, the total analysis time was less than 20 min, including 5 min for drying the TENAX and 5 min for thermal clesorption. Thus, SPETD-GC-MS appears to be a powerful tool for the rapid analysis of biological samples.

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Section: Selection Of the Stationary Phasementioning

confidence: 99%

Solid-phase extraction—Thermal desorption—Gas chromatography with mass selective detection for the determination of drugs in urine

et al. 2003

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“…However, in spite of the recent technical progress, the pesticide quantification in water requires a first step of extraction and preconcentration [6]. This sample preparation step is, in fact, the critical step of the whole analysis.…”

Section: Introductionmentioning

confidence: 99%

Multiresidue Method for Determination of 67 Pesticides in Water Samples Using Solid-Phase Extraction with Centrifugation and Gas Chromatography-Mass Spectrometry

Kouzayha¹,

Abdul²,

Mohamad³

et al. 2012

AJAC

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A new multi-residue method based on solid-phase extraction (SPE) with centrifugation was developed for determination and quantitation of 67 pesticides in water samples. Two SPE cartridges were tested: Chromabond C 18 and Oasis HLB. Parameters that influence the extraction efficiency such as the eluent volume, the sample loading volume, the addition of organic solvent to water sample, sorbent drying and elute concentration were optimized. The innovation of this work was the examination of the use of a centrifugation technique in both the drying and elution steps. When combined with centrifugation, the volume of the elution solvent was reduced to 2 mL and the time for sorbent drying decreased also to 10 min under vacuum. Under the optimized conditions, this method showed good recoveries higher than 65% -68% for the 67 analyzed pesticides using the C 18 and HLB cartridges with relative standard deviations lower than 9.7% -12.3%. Limits of quantification were between 2 and 20 ng·L -1 . The simplicity of the described method, use of less of organic solvent, short procedure time, and good recoveries demonstrate the advantages of this environmentally friendly approach for routine analysis of numerous samples.

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“…A number of interfaces have been developed for the (NP)LC-GC coupling, of which on-column, loop-type and vaporizer interfaces are commonly employed today [1,2,3,4,5,6]. The on-column and loop-type interfaces are usually applied with retention gap techniques and concurrent solvent evaporation techniques, respectively, for the evaporation of the solvent.…”

Section: How To Couple Lc and Gcmentioning

confidence: 99%

“…It should be noted that the coupling of RPLC to GC demands skill and special techniques, since aqueous RPLC eluents are unsuitable for direct transfer to GC and the interfacing techniques used in NPLC-GC generally do not work well for RPLC-GC. There are two ways to solve the problems related to RPLC-GC coupling [4,6]. Direct solutions to the problem of aqueous eluents rely on special techniques, whereas indirect solutions avoid them by phase switching, i.e.…”

Section: How To Couple Lc and Gcmentioning

confidence: 99%

Perspectives of on-line coupled liquid chromatography?gas chromatography

Hyötyläinen

Riekkola

2004

Analytical and Bioanalytical Chemistry

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On-line combination of aqueous-sample preparation and capillary gas chromatography

Cited by 55 publications

References 166 publications

Solid-phase extraction—Thermal desorption—Gas chromatography with mass selective detection for the determination of drugs in urine

Solid-phase extraction—Thermal desorption—Gas chromatography with mass selective detection for the determination of drugs in urine

Multiresidue Method for Determination of 67 Pesticides in Water Samples Using Solid-Phase Extraction with Centrifugation and Gas Chromatography-Mass Spectrometry

Perspectives of on-line coupled liquid chromatography?gas chromatography

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