On Left Ventricle Stroke Work Efficiency in Children with Moderate Aortic Valve Regurgitation or Moderate Aortic Valve Stenosis

Asaadi, Muftah; Mawad, Wadi; Djebbari, Abdelghani; Keshavardz-Motamed, Z.; Dahdah, Nagib; Kadem, Lyes

doi:10.1007/s00246-021-02690-2

Cited by 10 publications

(3 citation statements)

References 16 publications

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“… 68 In addition, some of the submodels of the lumped parameter model have been used and validated previously. 41 , 49 , 56 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 Moreover, the entire patient‐specific computational framework (LBM and lumped parameter model) was validated against clinical Doppler echocardiography previously. 44 Moreover, for all 26 patients investigated in this study, we observed good agreements between the simulated and experimental Doppler echocardiography pressure gradients (mean relative error, 3.9%).…”

Section: Resultsmentioning

confidence: 99%

Reducing Morbidity and Mortality in Patients With Coarctation Requires Systematic Differentiation of Impacts of Mixed Valvular Disease on Coarctation Hemodynamics

Sadeghi

Tomka

Khodaei

et al. 2022

JAHA

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Background Despite ongoing advances in surgical techniques for coarctation of the aorta (COA) repair, the long‐term results are not always benign. Associated mixed valvular diseases (various combinations of aortic and mitral valvular pathologies) are responsible for considerable postoperative morbidity and mortality. We investigated the impact of COA and mixed valvular diseases on hemodynamics. Methods and Results We developed a patient‐specific computational framework. Our results demonstrate that mixed valvular diseases interact with COA fluid dynamics and contribute to speed up the progression of the disease by amplifying the irregular flow patterns downstream of COA (local) and exacerbating the left ventricular function (global) (N=26). Velocity downstream of COA with aortic regurgitation alone was increased, and the situation got worse when COA and aortic regurgitation coexisted with mitral regurgitation (COA with normal valves: 5.27 m/s, COA with only aortic regurgitation: 8.8 m/s, COA with aortic and mitral regurgitation: 9.36 m/s; patient 2). Workload in these patients was increased because of the presence of aortic stenosis alone, aortic regurgitation alone, mitral regurgitation alone, and when they coexisted (COA with normal valves: 1.0617 J; COA with only aortic stenosis: 1.225 J; COA with only aortic regurgitation: 1.6512 J; COA with only mitral regurgitation: 1.3599 J; patient 1). Conclusions Not only the severity of COA, but also the presence and the severity of mixed valvular disease should be considered in the evaluation of risks in patients. The results suggest that more aggressive surgical approaches may be required, because regularly chosen current surgical techniques may not be optimal for such patients.

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Section: Resultsmentioning

confidence: 99%

Reducing Morbidity and Mortality in Patients With Coarctation Requires Systematic Differentiation of Impacts of Mixed Valvular Disease on Coarctation Hemodynamics

Sadeghi

Tomka

Khodaei

et al. 2022

JAHA

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“…The developed framework was validated against cardiac catheterization data with a considerable inter- and intra-patient variability with a broad range of diseases in a population of forty-nine patients (with AS). 20 Moreover, some of the sub-models of the patient-specific lumped parameter algorithm have been used previously, 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 with validation against in vivo cardiac catheterization 32 , 33 in patients with vascular diseases, in vivo magnetic resonance imaging data 34 in patients with AS, and in vivo magnetic resonance imaging data 35 , 36 , 37 in patients with mixed valvular diseases and coarctation.…”

Section: Methodsmentioning

confidence: 99%

Early Detection of Risk of Neo-Sinus Blood Stasis Post-Transcatheter Aortic Valve Replacement Using Personalized Hemodynamic Analysis

et al. 2023

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“…Especially if there is mixed AS and aortic insufficiency after an AoV repair, and even though a reintervention might be pushed to years away, the left ventricle will suffer. 3,4 Conversely, seeing the many teenagers with normal aortic roots after infant Ross, one can't help but think of the early Ross as being a better operation. In our hands, aside for patients who can be helped with simple AoV repairs, a wellexecuted Ross procedure, especially in young patients, remains the closest we can offer to a "cure" for the left side.…”

mentioning

confidence: 99%

Commentary: Can we ever “cure” aortic valve disease in children?

Bacha

2022

The Journal of Thoracic and Cardiovascular Surgery

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On Left Ventricle Stroke Work Efficiency in Children with Moderate Aortic Valve Regurgitation or Moderate Aortic Valve Stenosis

Cited by 10 publications

References 16 publications

Reducing Morbidity and Mortality in Patients With Coarctation Requires Systematic Differentiation of Impacts of Mixed Valvular Disease on Coarctation Hemodynamics

Reducing Morbidity and Mortality in Patients With Coarctation Requires Systematic Differentiation of Impacts of Mixed Valvular Disease on Coarctation Hemodynamics

Early Detection of Risk of Neo-Sinus Blood Stasis Post-Transcatheter Aortic Valve Replacement Using Personalized Hemodynamic Analysis

Commentary: Can we ever “cure” aortic valve disease in children?

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