On Hypertrophy and Atrophy of the Brain

Sims, John A.

doi:10.1177/095952873501900120

Cited by 38 publications

(14 citation statements)

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“…The description of several focal MCD subtypes such as HME and TSC dates back to the 1800s (Sims 1835;Bourneville 1880), whereas focal cortical dysplasia was first described in the 1970s (Taylor et al 1971). With the accessibility of more advanced neuroimaging in the 1990s, specifically brain MRI, it became apparent that focal MCD were more common than thought previously in patients with intractable epilepsy.…”

Section: Classification Of Focal MCDmentioning

confidence: 96%

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

Crino

2015

Cold Spring Harbor Perspectives in Medicine

143

111

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Section: Classification Of Focal MCDmentioning

confidence: 96%

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

Crino

2015

Cold Spring Harbor Perspectives in Medicine

143

111

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“…4 The exact pathogenesis of this neurodevelopmental disorder remains unknown. Hamartomatous malformation, heteroploidy, disorders of migration, vascular lesion, and neoplasm have been proposed based on pathological, immunocytochemical, and biochemical studies of resected or autopsied brains.…”

Section: Discussionmentioning

confidence: 99%

Hemimegalencephaly: cranial sonographic findings in neonates

Hung¹,

Wang²

2005

J of Clinical Ultrasound

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Hemimegalencephaly is a rare neuronal migration disorder characterized by overgrowth of part or all of 1 cerebral hemisphere. Lissencephaly, pachygyria, polymicrogyria, heterotopia, and glial abnormalities are usually noted pathologically in the enlarged hemisphere. We report the sonographic changes associated with hemimegalencephaly in 2 neonates presenting with seizures and correlate these changes with the magnetic resonance imaging findings.

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“…A HME foi descrita pela primeira vez por Sims em 1835 e caracteriza-se por proliferação neuronal excessiva com aumento de um hemisfério cerebral, dilatação e configuração irregular dos ventrículos e graus variáveis de displasia cortical, incluindo heterotopias, lisencefalia, polimicrogiria e anormalidades vasculares [3][4][5] . O mecanismo determinante desta malformação é desconhecido.…”

Section: Discussionunclassified

Hemisferectomia funcional precoce na hemimegalencefalia associada à epilepsia refratária

Fonseca

Melo

Cukiert

et al. 2004

Arq. Neuro-Psiquiatr.

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RESUMO -A hemimegalencefalia (HME) é malformação congênita cerebral rara de etiologia desconhecida que pode se apresentar com síndrome epiléptica de início precoce e resistente à terapia com anticonvulsivantes, associada a comprometimento significativo do desenvolvimento neuropsicomotor. A hemisferectomia funcional (HF) tem-se mostrado alternativa eficaz nos casos refratários à terapêutica medicamentosa. Em número diminuto, crianças foram operadas antes dos seis meses de idade. Esse estudo relata duas crianças com idade inferior a 6 meses com HME e síndrome epiléptica catastrófica submetidas a HF e com boa evolução clínica.PALAVRAS-CHAVE: hemimegalencefalia, hemisferectomia, epilepsia. Early functional hemispherectomy in hemimegalencephaly associated to refractory epilepsyABSTRACT -Hemimegalencephaly (HME) is a rare congenital brain malformation of unknown etiology. Patients with HME can present with an early onset epileptic syndrome which is often refractory to medical treatment and associated to impaired neurological development. Functional hemispherectomy (FH) has proven to be a valuable treatment alternative in patients with refractory epilepsy in this setting. Very few children operated under the age of 6 months and bearing HME and catastrophic epilepsy (CE) have been described in the literature. This study reports on 2 kids younger than 6 months with HME and CE submitted to FH with good clinical outcome.

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On Hypertrophy and Atrophy of the Brain

Abstract: * Repertoire General d'Anatomie et de Physiologie Pathologique, &c. Tome V. p. 197. I have not been able to meet with the Number of the Revue MUdicale, containing the Essay of M4de. Labnnec on Hypertrophy of the Brain.

Cited by 38 publications

References 0 publications

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

Hemimegalencephaly: cranial sonographic findings in neonates

Hemisferectomia funcional precoce na hemimegalencefalia associada à epilepsia refratária

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