On Glandular Structures at the Corneo‐scleral Junction in Man and Swine; The So‐called «manz‘ Glands»

Abstract

In 1859 Manz gave an account of some peculiar structures at the corneo-scleral junction in swine and, although their nature as true glands has been disputed, they have been called >>M anz' glands<<.According to Manz they were round vesicles with oval stomata, surrounded by a prominence. The inner wall of the vesicles was covered by epithelium. They contained large round cells and a fine granulated pulp. Most of the vesicles were situated on the nasal side of the cornea, some on the temporal side and only few at the upper and lower border of the cornea. Manz supposed, that they took part in the formation of the )>conjunctival humour<<. Later these structures were objects for investigations and considerations by many authors but with only slight success. As a consequence of faulty interpreations and misconceptions there has been a considerable confusion of ideas.Some authors even doubt their existence. Thus, Zietschniann (1906) did not find them in any animal. Others for instance Arnold (1862) and Henle (1863, 1873) deny categorically their existence and look upon )>the glands of Manzcc as wrongly apprehended sections of conjunctival folds. Other authors only speak about >>heaps of cells in limbar folds<< in swine, which show neither lumen nor other characteristics of *) Received June 2nd 19/18. 2*

Ectopic Lacrimal Gland Tissue at the Corneal Limbus (Gland of Manz?)

“…I n agreement with M a n z ( 18,58), Aurell & Kornerup (1949) found that the glands of Manz werc prexcnt only in the pig in the form of rudimentary lacrimal glands nasal to the cornea, and this is now generally accepted (Duke-Elder 1961).…”

Autologous Limbal Stem Cell Transplantation: The Progression of Diagnosis and Treatment

“…Ninety years later, in 1949, Aurell and Kornerup suggested that these so called ''glands of Manz'' were rudimentary components of the lacrimal apparatus responsible for secreting mucin. 3 As recently as 1961, Duke-Elder considered the palisades of Vogt to be functionless vestigial remnants of these glands. 4 It was not until 2005 that Dua et al 5 demonstrated histologically the existence of limbal epithelial crypts within the palisades of Vogt, structures that accurately fit Manz's original description nearly 150 years prior.…”

Corneal and superficial conjunctival pigmentation in Eskimos, Mongols, and Caucasians

“…eye. Corneal pigmentation may occur in limbal crypts (Aurell & Kornerup 1949) and perilimbal pigmentation as complete ring round the cornea. H. Virchow (1910) found such pigmentation in more than 0.3% of Caucasians (cited in Duke Elder…”