We propose a matrix analogue of a general inverse series relation with an objective to introduce the generalized Humbert matrix polynomial, Wilson matrix polynomial, and the Rach matrix polynomial together with their inverse series representations. The matrix polynomials of Kiney, Pincherle, Gegenbauer, Hahn, Meixner-Pollaczek etc. occur as the special cases. It is also shown that the general inverse matrix pair provides the extension to several inverse pairs due to John Riordan [An Introduction to Combinatorial Identities, Wiley, 1968].