On Excluding Monoclonal Gammopathy

Ruı́z-Argüelles, Alejandro; Valls-de-Ruiz, M; Ruíz‐Argüelles, Guillermo J.; Barranco, Alfonso DomÞnguez

doi:10.1093/ajcp/81.3.409

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with the antiphospholipid syndrome (APS) suffer a thrombophilic condition characterized by multiple defects such as acquired deficiencies of protein C (PC), protein S (PS), and antithrombin III (AT III) (1); impaired fibrinolysis (2); increased levels of lipoprotein (a) (3); vasculopathy (4); activated PC resistance (5-7), etc. Some, but not all, of these changes have been related to the presence of antiphospholipid antibodies (APA), lupus anticoagulants (LAs), and autoantibodies directed towards PC (8); PS (9); AT III (10), tissue-type plasminogen activator (11), thrombomodulin (12), and other phospholipid-binding plasma proteins (13).…”

mentioning

confidence: 99%

“…Some, but not all, of these changes have been related to the presence of antiphospholipid antibodies (APA), lupus anticoagulants (LAs), and autoantibodies directed towards PC (8); PS (9); AT III (10), tissue-type plasminogen activator (11), thrombomodulin (12), and other phospholipid-binding plasma proteins (13). The APS may be associated with systemic lupus erythematosus (14)(15) or have no associated condition (primary APS) (16)(17).…”

mentioning

confidence: 99%

See 1 more Smart Citation

The G20210A Polymorphism in the 3' -Untranslated Region of the Prothrombin Gene in Mexican Mestizo Patients with Primary Antiphospholipid Syndrome

Ruíz‐Argüelles

Garcés‐Eisele

Ruíz-Delgado

et al. 1999

Clin Appl Thromb Hemost

Self Cite

View full text Add to dashboard Cite

In an effort to identify alleles associated with an increased risk of venous thrombosis in patients with primary antiphospholipid syndrome, we studied the G20210A polymorphism (the G-->A mutation at nucleotide position 20210) in the 3'-untranslated region of the prothrombin gene in a group of 14 patients with primary antiphospholipid syndrome. We did not find any patient with the mutated gene. Since the prothrombin mutation is more prevalent in white populations, this finding may be related with the genetic composition of the Mexican mestizos, in whom the white component is low. The polymorphism of the prothrombin gene in Mexican mestizo patients with antiphospholipid syndrome does not seem to be related to the thrombophilia observed in these patients.

show abstract

mentioning

confidence: 99%