The statistical side information of interference channels is exploited in this paper to derive a novel uncoordinated on-line pilot design strategy for opportunistic communications. Assuming a time division duplex (TDD), or frequency division duplex (FDD) with feedback, wireless network and reciprocity, we prove that the space-frequency pilot design technique in terms of minimum cross-interference to external-network users reduces to a classical minimum-norm problem. The advantages of this novel methodology are time-domain invariance to noise-subspace rotations, a maximally flat angle-frequency response, and robustness in front of frequency calibration errors. Simulation results are reported to assess the performance of the proposed strategy and the advantages of its low-resolution quantization in low signal-tonoise ratio (low-SNR) regimes. Index Terms-Opportunistic communications, pilot and waveform design, multi-antenna systems, distributed networks, wideband regime.