On Distributions of Physiological and Anatomical Variables in Pathological Conditions: Dopamine D2 Receptors in Schizophrenia and Their Occupancies after Drug Treatment
Abstract:If a physiological, biochemical or anatomical variable has a normal distribution then the tails of such a distribution may be associated with pathological function. In certain cases this can lead to a bimodal distribution for the variable in individuals with the resultant pathology. We illustrate with a study of dopamine receptors. PET data suggest that the distribution of dopamine DA2 receptor densities in schizophrenic patients might be bimodal. A quantitative model based on the classical theory of drug acti… Show more
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