Abstract. A set of m positive integers {a 1 , . . . , am} is called a Diophantine m-tuple if the product of any two elements in the set increased by one is a perfect square. The conjecture according to which there does not exist a Diophantine quintuple is still open. In this paper, we show that if {a, b, c, d, e} is a Diophantine quintuple with a < b < c < d < e, then b > 3 a; moreover, b > max{21 a, 2 a 3/2 } in case c > a + b + 2 √ ab + 1.