On demand therapy with omeprazole for the long‐term management of patients with heartburn without oesophagitis—a placebo‐controlled randomized trial

Lind, Tore; Havelund, Troels; Lundell, Lars; Glise, Hans; Lauritsen, K; Pedersen, Sidsel Arnspang; Anker-Hansen, O; Stubberöd, A; Eriksson, Gina; Carlsson, R.; Junghard, Ola

doi:10.1046/j.1365-2036.1999.00564.x

Cited by 189 publications

(159 citation statements)

References 22 publications

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“…However, in cases in which treatment was continued for at least six or more months after four or eight weeks of first-line treatment, both endoscopic and symptomatic remission rates were found to be higher than in the group not receiving treatment. In the study by Lind et al (22), higher symptomatic remission rates were detected at the end of the 6 th month in patients using 20 mg/day or 10 mg/day omeprazole during 6 months of maintenance treatment after first-line treatment compared to the placebo group (83%, 70%, and 56%, respectively). Similarly, higher symptomatic remission rates were found in cases using rabeprazole at the treatment dose for 6 months after first-line treatment than in the cases receiving placebo during maintenance treatment (86.7% vs. 74.9%, p<0.02) (23).…”

Section: Cessation Of the Treatment In Patients With Gerdmentioning

confidence: 99%

Medical treatment of gastroesophageal reflux disease

Bor

Kalkan

2017

Turk J Gastroenterol

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Section: Cessation Of the Treatment In Patients With Gerdmentioning

confidence: 99%

Medical treatment of gastroesophageal reflux disease

Bor

Kalkan

2017

Turk J Gastroenterol

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“…9 There is increasing support for the on-demand approach as the preferred strategy. [10][11][12] For example, Bardhan et al prospectively enrolled 526 patients and treated them with either an H 2 RA or proton pump inhibitor taken as needed. 10 Approximately 50% of the patients did not need to take any acid-suppressive medication for a minimum of 6 of the 12 months of the study.…”

Section: Choice Of Strategymentioning

confidence: 99%

Overview: initial and long‐term management of gastro‐oesophageal reflux disease

Talley

2003

Aliment Pharmacol Ther

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Summary Initial management of gastro‐oesophageal reflux disease aims to confirm a symptom‐based diagnosis, to relieve symptoms, to reassure the patient as to the treatable nature of reflux disease, and to initiate risk management and healing of oesophagitis. The aims of long‐term management include adequate control of symptoms, prevention of complications, and improvement of quality of life. Management options in terms of use of proton pump inhibitors are either daily therapy (maintenance), intermittent courses of therapy (for example, 4 weeks, then cease and observe), or on‐demand therapy. This overview discusses the advantages and disadvantages of these different strategies for the management of reflux disease.

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“…However, like functional heartburn, one cannot differentiate among any of the phenotypic presentations of GERD and heartburn-related functional esophageal disorders, using patients' severity, frequency, or duration of heartburn symptoms. 27 Overlap symptoms with other functional bowel disorders, GERD and psychological comorbidity are not uncommon. 5,28 A recent study suggested that anxiety may be more common in reflux hypersensitivity patients as compared with functional heartburn patients.…”

Section: Clinical Presentationmentioning

confidence: 99%

Reflux Hypersensitivity: A New Functional Esophageal Disorder

Yamasaki

Fass

2017

J Neurogastroenterol Motil

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Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and esophageal biopsies, normal esophageal pH test and with evidence of a close correlation between patients' heartburn and reflux events. Reflux hypersensitivity is very common and together with functional heartburn accounts for more than 90% of the heartburn patients who failed treatment with proton pump inhibitor twice daily. In addition, reflux hypersensitivity affects primarily young to middle aged women, commonly overlaps with another functional gastrointestinal disorders, and is often associated with some type of psychological comorbidity. Diagnosis is made by using endoscopy with esophageal biopsies, pH-impedance, and high-resolution esophageal manometry. Reflux hypersensitivity is primarily treated with esophageal neuromodulators, such as tricyclic anti-depressants and selective serotonin reuptake inhibitors among others. Surgical anti-reflux management may also play an important role in the treatment of reflux hypersensitivity.

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On demand therapy with omeprazole for the long‐term management of patients with heartburn without oesophagitis—a placebo‐controlled randomized trial

Abstract: Approximately 50% of patients with heartburn who do not have oesophagitis need acid inhibitory therapy in addition to antacid medication to maintain a normal quality of life. On-demand therapy with omeprazole 20 mg, is an effective treatment strategy in these patients.

Cited by 189 publications

References 22 publications

Medical treatment of gastroesophageal reflux disease

Medical treatment of gastroesophageal reflux disease

Overview: initial and long‐term management of gastro‐oesophageal reflux disease

Reflux Hypersensitivity: A New Functional Esophageal Disorder

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