On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing

Aita, Ilias El; Breitkreutz, Jörg; Quodbach, Julian

doi:10.1016/j.ejpb.2018.11.008

Cited by 90 publications

(37 citation statements)

References 20 publications

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“…Several drying conditions (process types, temperature, and duration) are reported for PAM 3D printing. El Aita et al investigated the drying process and found only 3 h of drying at 200 mbar in a vacuum dryer was sufficient for the complete drying (loss on drying, LOD, <1%) of their printed structure [148]. Other drying conditions reported as using a vacuum dryer at 40 • C for 24 h [18,76,139], on the heated printing platform at 80 • C for 3 h [149], in an oven at 40 • C for 12 h [150,151], left at 20 • C for 12 h [152], in an incubator containing a silica gel bead cartridge at 40 • C for 24 h [63] etc.…”

Section: Dosage Shape Size Complexitymentioning

confidence: 99%

“…Other drying conditions reported as using a vacuum dryer at 40 • C for 24 h [18,76,139], on the heated printing platform at 80 • C for 3 h [149], in an oven at 40 • C for 12 h [150,151], left at 20 • C for 12 h [152], in an incubator containing a silica gel bead cartridge at 40 • C for 24 h [63] etc. Drying effect on structure and properties of the finished products are reported as during the drying process shell formation may occur on the outer surface of the tablet which might cause inefficient drying and result in the mechanical properties (friability, hardness) of the tablet [148], deformation of the structure [63,76,150], formation of pores on the surface [152], paste shrinkage [139], etc. The mechanical strength of 3D printed tablets is also important.…”

Section: Dosage Shape Size Complexitymentioning

confidence: 99%

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Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

et al. 2020

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Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer–active pharmaceutical ingredient (API) combinations, impact the printing process. Especially, understanding the rheology of the polymer and API–polymer mixtures is necessary for successful 3D printing of dosage forms or printed structures. This review has summarized a holistic materials–process perspective for polymers on extrusion-based 3D printing. The main focus herein will be both FDM and PAM 3D printing processes. It elaborates the discussion on the comparison of 3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients. The current technological challenges, regulatory aspects, and the direction toward which the technology is moving, especially for personalized pharmaceuticals and multi-drug printing, are also briefly discussed.

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Section: Dosage Shape Size Complexitymentioning

confidence: 99%

Section: Dosage Shape Size Complexitymentioning

confidence: 99%

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

et al. 2020

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“…Nozzle-based deposition systems encompass two main groups: pressure-assisted microsyringe (PAM) and fused deposition modeling (FDM). In the first system, the material is extruded through the nozzle syringe thanks to a pneumatic mechanism, a piston or a screw, which provides the material to build the structure [ 28 ] (see Figure 2 ). In FDM, the extrusion process entails nozzle heating, in order to melt and deposit the material in the building plate [ 29 ].…”

Section: Nozzle-based Deposition Systemsmentioning

confidence: 99%

3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

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In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.

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“…Such limitations can potentially be overcome with the establishment of novel technologies like 3D printing, which is emerging as a promising tool for the on-demand production of oral dosage forms [74]. Low cost, compact size and almost unlimited production flexibility make 3D printing a frontrunner technology capable of being employed in various scenarios where the same machine can be used to fabricate personalised medicines, prosthesis, equipment and even to synthesise APIs [75][76][77].…”

Section: On-demand Production Of Drug Productsmentioning

confidence: 99%

Current formulation approaches in design and development of solid oral dosage forms through three-dimensional printing

2020

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printing technologies are continuously applied to novel fields, laying the foundations for a new industrial revolution. With regard to pharmaceutical sciences, 3D printed drug products are emerging as attractive and innovative tools in personalised medicine. For example, solid oral dosage forms (e.g. tablets) can be printed in a wide range of dosages, release profiles, geometries and sizes by simply modifying a digital model, thus providing patients with tailored therapies. Various 3D printing technologies have been applied to pharmaceutical manufacture in recent years, and different materials have been investigated to fabricate solid oral dosage forms in a broad range of properties. Therefore, the aim of this review is to describe the state of the art of 3D printing oral pharmaceuticals, with the view to provide formulation scientists with essential information to approach the development of 3D printed drug products, from digital design to final product quality control. Short-to long-term potential areas of application of 3D printed drug products and their relative regulatory pathway challenges are also presented.

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On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing

Cited by 90 publications

References 20 publications

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

3D Printed Drug Delivery Systems Based on Natural Products

Current formulation approaches in design and development of solid oral dosage forms through three-dimensional printing

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