On-demand electrostatic droplet charging and sorting

Ahn, Byungwook; Lee, Kangsun; Panchapakesan, Rajagopal; Oh, Kwang W.

doi:10.1063/1.3604393

Cited by 49 publications

(40 citation statements)

References 18 publications

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“…에서 활발히 연구되고 있다 [1][2][3][4][5][6][7][8][9][10][11][12]. 액적 접촉충전 현상 기반의 미세 유체 기술은 개별 액적을 전기를 이용해 다루는 디지털 미세유체 기 술의 한 분야로 [13,14], 채널 내 액적을 다루는 액적 미세유체 (Droplet Microfluidics) [15,16] 기술과는 다르며 기존 미세유체 기술 들의 단점을 극복할 수 있어 새로운 대안 기술로 제시되고 있는 신 기술 이다 [17,18].…”

Section: 서 론 최근 새로운 미세유체 기술로써 액적 접촉충전 현상이 여러 분야unclassified

Contact Charging and Electrphoresis of a Glassy Carbon Microsphere

Choi¹,

Im²

2016

Korean Chemical Engineering Research

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− We investigated the charging characteristics of a conducting solid sphere (glassy carbon sphere) comparing with that of a water droplet and check the applicability of the perfect conductor theory. For the systematic research, sphere size, applied voltages, viscosity of the medium were changed and the results were compared with that of corresponding water droplets and the perfect conductor theory. Basically, a glassy carbon sphere follows the perfect conductor theory but the charging amount was lower as much as 70~80% of theoretical prediction value due to oil film formed between electrode and a carbon sphere. We hope this result provides basic understandings on the solid sphere contact charging phenomenon and related applications.

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Section: 서 론 최근 새로운 미세유체 기술로써 액적 접촉충전 현상이 여러 분야unclassified

Contact Charging and Electrphoresis of a Glassy Carbon Microsphere

Choi¹,

Im²

2016

Korean Chemical Engineering Research

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“…The charges originate from the grounded electrode that has no insulating layer (see Figure 1f). The charges remain in the droplet as it detaches from the electrodes resulting in a charged droplet [60].…”

Section: Pre-chargingmentioning

confidence: 99%

Droplet Manipulations in Two Phase Flow Microfluidics

2015

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Even though droplet microfluidics has been developed since the early 1980s, the number of applications that have resulted in commercial products is still relatively small. This is partly due to an ongoing maturation and integration of existing methods, but possibly also because of the emergence of new techniques, whose potential has not been fully realized. This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics. Specifically, very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed. The physical principles are explained, and (potential) advantages and drawbacks of different methods in the sense of versatility, flexibility, tunability and durability are discussed, where possible, per technique and per droplet operation: generation, transport, sorting, coalescence and splitting.

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“…[1][2][3][4] The manipulation of individual droplets allows the reagents to be transported, merged, mixed, and analyzed as a micro-reactor effectively and quickly. [5][6][7][8][9][10][11][12][13] The technology has been considered as a promising platform due to the need for automated highthroughput systems for various chemical and biological analyses.…”

Section: Introductionmentioning

confidence: 99%

Droplet-based microfluidic washing module for magnetic particle-based assays

Lee

2014

Biomicrofluidics

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In this paper, we propose a continuous flow droplet-based microfluidic platform for magnetic particle-based assays by employing in-droplet washing. The dropletbased washing was implemented by traversing functionalized magnetic particles across a laterally merged droplet from one side (containing sample and reagent) to the other (containing buffer) by an external magnetic field. Consequently, the magnetic particles were extracted to a parallel-synchronized train of washing buffer droplets, and unbound reagents were left in an original train of sample droplets. To realize the droplet-based washing function, the following four procedures were sequentially carried in a droplet-based microfluidic device: parallel synchronization of two trains of droplets by using a ladder-like channel network; lateral electrocoalescence by an electric field; magnetic particle manipulation by a magnetic field; and asymmetrical splitting of merged droplets. For the stable droplet synchronization and electrocoalescence, we optimized droplet generation conditions by varying the flow rate ratio (or droplet size). Image analysis was carried out to determine the fluorescent intensity of reagents before and after the washing step. As a result, the unbound reagents in sample droplets were significantly removed by more than a factor of 25 in the single washing step, while the magnetic particles were successfully extracted into washing buffer droplets. As a proof-of-principle, we demonstrate a magnetic particle-based immunoassay with streptavidin-coated magnetic particles and fluorescently labelled biotin in the proposed continuous flow dropletbased microfluidic platform. V C 2014 AIP Publishing LLC.

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On-demand electrostatic droplet charging and sorting

Cited by 49 publications

References 18 publications

Contact Charging and Electrphoresis of a Glassy Carbon Microsphere

Contact Charging and Electrphoresis of a Glassy Carbon Microsphere

Droplet Manipulations in Two Phase Flow Microfluidics

Droplet-based microfluidic washing module for magnetic particle-based assays

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