On-Demand Current Pulse Activation of RF Monopole Antenna Biosensor Arrays with Nitrocellulose Membranes

Shanmugadas, Sindu; Lundsquit, Jonathan; Topsakal, Erdem; Özgür, Ü.; Avrutin, Vitaliy

doi:10.23919/usnc-ursinrsm57467.2022.9881408

Cited by 1 publication

(2 citation statements)

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“…The data show that sensor well activation can occur in the high tens of millijoules energy range. This is similar to results obtained in previous data in which an electron beam and thermal deposition were used for filament application [36][37][38]. Electron beam and thermal evaporation, as well as sputtering, are costly thin metal deposition methods.…”

Section: Discussionsupporting

confidence: 90%

“…The array can also be composed of different types of biosensors targeting different analytes. Activation could be achieved through the use of membranes based on an energetic polymer such as nitrocellulose being heated with a resistive filament using a current pulse [36][37][38]. The filament is used to concentrate power loss of the applied current pulse directly on the membrane, thereby igniting the nitrocellulose and disintegrating the membrane that is separating the biofluid from the sensor being placed online.…”

Section: Introductionmentioning

confidence: 99%

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Energy-Efficient, On-Demand Activation of Biosensor Arrays for Long-Term Continuous Health Monitoring

et al. 2022

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Wearable biosensors for continuous health monitoring, particularly those used for glucose detection, have a limited operational lifetime due to biodegradation and fouling. As a result, patients must change sensors frequently, increasing cost and patient discomfort. Arrays of multiple sensors, where the individual devices can be activated on demand, increase overall operational longevity, thereby reducing cost and improving patient outcomes. This work demonstrates the feasibility of this approach via decomposition of combustible nitrocellulose membranes that protect the individual sensors from exposure to bioanalytes using a current pulse. Metal contacts, connected by graphene-loaded PEDOT:PSS polymer on the surface of the membrane, deliver the required energy to decompose the membrane. Nitrocellulose membranes with a thickness of less than 1 µm consistently transfer on to polydimethylsiloxane (PDMS) wells. An electrical energy as low as 68 mJ has been shown to suffice for membrane decomposition.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%