“On-command” dissolvable tympanostomy tube in the chinchilla model: A proof of concept

Wiedermann, Joshua; Johnny, P.; Dumont, Matthieu; Jenkins, Audrey L.; Cleary, Kevin; Reilly, Brian K.

doi:10.1016/j.ijporl.2017.07.017

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…In attempts to reduce the incidence of retained TTs, Brian Reilly and colleagues at Children's National Hospital are engineering a biocompatible tube material that will dissolve ''oncommand'' upon contact with a unique ototopical compound. 8 Biocompatibility in the rat model demonstrated no pathologic or reactive tissue surrounding tube placement. 8,9 The tube material showed resistance to degradation with application of Ciprofloxacin and Ciprodex drops, while both ethanol and hydrogen peroxide successfully degraded the tubes over a period of 48 hours.…”

Section: Innovation In Tt Materials and Designmentioning

confidence: 96%

“…8 Biocompatibility in the rat model demonstrated no pathologic or reactive tissue surrounding tube placement. 8,9 The tube material showed resistance to degradation with application of Ciprofloxacin and Ciprodex drops, while both ethanol and hydrogen peroxide successfully degraded the tubes over a period of 48 hours. Given potential ototoxicity associated with ethanol use, further efforts to achieve the ideal degradation agent are ongoing.…”

Section: Innovation In Tt Materials and Designmentioning

confidence: 96%

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Tympanostomy Tube Innovation: Advances in Device Material, Design, and Office-Based Technology

Whelan

Maguire

2020

Ear Nose Throat J

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Objectives: With tympanostomy tube insertion remaining the most common procedure performed in children to date, growing interests in minimizing both procedural costs and anesthetic exposure in the pediatric population have inspired innovation with respect to tympanostomy tubes. As such, we aim to discuss the current state of tympanostomy tube innovation including insertion devices, tube material, and design. Methods: Computerized literature review. Results: (1) Numerous single-use devices consisting of a myringotomy knife and preloaded tympanostomy tube offer potential advantages of decreasing or eliminating operating room time and may be performed under moderate instead of a general anesthetic. (2) Innovation with respect to tympanostomy tube material and design may offer enhanced ototopical drug delivery, decreased rates of tube occlusion, and/or the ability to dissolve “on-command” with application of a novel ototopical material. (3) These technologies currently remain in various phases of preclinical and clinical testing. Conclusions: While clinical testing for a number of new technologies is preliminary and ongoing, tympanostomy tube-related innovations hold exciting promise to supplement or potentially replace the present-day armamentarium of tympanostomy tube design and insertion moving forward.

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Section: Innovation In Tt Materials and Designmentioning

confidence: 96%