On chronological changes in the basic EEG rhythm in persons with Down syndrome – with special reference to slowing of alpha waves

Katada, Akiyoshi; Hasegawa, Sakurako; Ohira, Dan; Kumagai, Takako; Harashima, Tsuneo; Ozaki, Hisaki; Suzuki, Hideji

doi:10.1016/s0387-7604(00)00107-8

Cited by 25 publications

(23 citation statements)

References 12 publications

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“…Slowing of alpha background frequency in DS, as found in this study, has been consistently reported in DS [Devinsky et al,1990; Katada et al,2000; Ono,1993; Ono et al,1992; Partanen et al,1996; Politoff et al,1996] and found in parallel with enlarged third ventricles [Devinsky et al,1990]. Results regarding alpha changes have been attributed to possible thalamic atrophy, leading to loss of normal alpha background, while enlargement of the ventricles has been hypothesized to be related to thalamic degeneration [Devinsky et al,1990].…”

Section: Discussionsupporting

confidence: 88%

“…The leading EEG abnormalities in DS, according to the literature, have been attributed to alpha oscillations [Devinsky et al,1990; Kaneko et al,1996; Katada et al,2000; Ono,1993; Ono et al,1992; Partanen et al,1996; Politoff et al,1996; Schmid et al,1985]. Some authors, however, found parallel with alpha changes in theta [Ono,1993; Schmid et al,1985], or in all bands [Politoff et al,1996], whereas others describe (mainly in demented patients) abnormalities restricted in lower delta and theta frequencies [Medaglini et al,1997].…”

Section: Introductionmentioning

confidence: 99%

“…Further, analysis on chronological changes of alpha waves in DS has shown that the slowing in DS starts in the central and frontal regions and later extends to the occipital, in contrast to healthy subjects where the slowing starts in occipital regions while in the central and frontal areas it seems to occur at a higher age [Katada et al,2000]. These changes seem different from those observed in other forms of mental retardation, with a later onset of alpha rhythm slowing and a slower progression rate [Katada et al,2000].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive impairment and EEG background activity in adults with Down's syndrome: A topographic study

Velikova

Magnani

Arcari

et al. 2011

Human Brain Mapping

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive impairment and EEG background activity in adults with Down's syndrome: A topographic study

Velikova

Magnani

Arcari

et al. 2011

Human Brain Mapping

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“…In adults with DS over age 45 years, those with seizures are more likely to develop dementia [7]. Decreasing EEG frequency in the occipital lobes in DS has been related to dementia [45]. Paroxysmal activity was noted in a minority of our subjects on sporadic EEGs.…”

Section: Discussionmentioning

confidence: 93%

Down Syndrome and Dementia: Seizures and Cognitive Decline

Lott

Doran

Nguyen

et al. 2012

JAD

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The objective of this study was to determine the association of seizures and cognitive decline in adults with Down syndrome (DS) and Alzheimer's-type dementia. A retrospective data analysis was carried out following a controlled study of antioxidant supplementation for dementia in DS. Observations were made at baseline and every 6 months for 2 years. Seizure history was obtained from study records. The primary outcome measures comprised the performance-based Severe Impairment Battery (SIB) and Brief Praxis Test (BPT). Secondary outcome measures comprised the informant-based Dementia Questionnaire for Mentally Retarded Persons and Vineland Adaptive Behavior Scales. Because a large proportion of patients with seizures had such severe cognitive decline as to become untestable on the performance measures, time to “first inability to test” was measured. Adjustments were made for the potentially confounding co-variates of age, gender, APOE44 status, baseline cognitive impairment, years since dementia onset at baseline, and treatment assignment. The estimated odds ratio for the time to “first inability to test” on the SIB comparing those with seizures to those without is 11.02 (95% CI: 1.59, 76.27), a ratio that is significantly different from 1 (p = 0.015). Similarly, we estimated an odds ratio of 9.02 (95% CI: 1.90, 42.85) on the BPT, a ratio also significantly different than 1 (p = 0.006). Results from a secondary analysis of the informant measures showed significant decline related to seizures. We conclude that there is a strong association of seizures with cognitive decline in demented individuals with DS. Prospective studies exploring this relationship in DS are indicated.

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“…Abnormalities in the waking EEG have also been reported. These include a slower alpha band (8)(9)(10)(11)(12) and/or an increase in theta band power (4-8 Hz) (Hirai and Izawa, 1964, Schmid et al, 1985, Politoff et al, 1996, Katada et al, 2000 during wake. Waking EEG spectra abnormalities have been found to correlate with cognitive difficulties, suggesting clinical relevance (Politoff et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Sleep and EEG features in genetic models of Down syndrome

Colas

Valletta

Takimoto-Kimura

et al. 2008

Neurobiology of Disease

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Down syndrome is characterized by a host of behavioral abnormalities including sleep disturbances. Sleep and EEG was studied at the age of 3 months in two mouse models of the condition, Ts65Dn and Ts1Cje, carrying one extra copy of partially overlapping segments of the mmu chromosome 16 (equivalent to the human chromosome 21). We found that the Ts65Dn mice showed increased waking amounts at the expense of non-REM sleep, increased theta power during sleep and a delayed sleep rebound after sleep deprivation. In contrast, Ts1Cje had limited sleep and EEG abnormalities, showing only a delayed sleep rebound after sleep deprivation and no difference in theta power. We previously found that mice over-expressing the human APPwt transgene, a gene triplicated in Ts65Dn but not Ts1Cje, also show increased wake and theta power during sleep. These results demonstrate abnormalities in sleep and EEG in Ts65Dn mice and underscore a possible correlation between App overexpression and hippocampal theta oscillations.

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On chronological changes in the basic EEG rhythm in persons with Down syndrome – with special reference to slowing of alpha waves

Cited by 25 publications

References 12 publications

Cognitive impairment and EEG background activity in adults with Down's syndrome: A topographic study

Cognitive impairment and EEG background activity in adults with Down's syndrome: A topographic study

Down Syndrome and Dementia: Seizures and Cognitive Decline

Sleep and EEG features in genetic models of Down syndrome

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