On approximation measures of q-exponential function

Leinonen, L.; Leinonen, Marko E.; Matala-aho, Tapani

doi:10.1142/s1793042116500172

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Significantly delayed latencies in both waveforms arose by 30 months in both sexes of CLN3 Δex7/8 animals ( Fig. 2 G,H), suggestive of defects in photoreceptor neuronal transmission ( Leinonen, 2016 ). In general, photoreceptor death results in loss of amplitude, while photoreceptor dysfunction results in delayed amplitudes.…”

Section: Resultsmentioning

confidence: 96%

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes

Swier

White

Johnson

et al. 2023

Disease Models &Amp; Mechanisms

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Mouse models of CLN3 Batten disease, a rare lysosomal storage disorder with no cure, have improved our understanding of CLN3 biology and therapeutics through their ease of use and a consistent display of cellular pathology. However, the translatability of murine models is limited by disparities in anatomy, body size, life span, and inconsistent, subtle behavior deficits that can be difficult to detect in CLN3 mutant mouse models, limiting their utility in preclinical studies. Here we present a longitudinal characterization of a novel miniswine model of CLN3 disease that recapitulates the most common human pathogenic variant, an exon 7-8 deletion (CLN3Δex7/8). Progressive pathology and neuron loss is observed in various regions of the CLN3Δex7/8 miniswine brain and retina. Additionally, mutant miniswine present with retinal degeneration and motor abnormalities, similar to deficits seen in human patients. Taken together, the CLN3Δex7/8 miniswine model shows consistent and progressive Batten disease pathology and behavioral impairment mirroring clinical presentation, demonstrating its value in studying the role of CLN3 and safety/efficacy of novel disease modifying therapeutics.

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Section: Resultsmentioning

confidence: 96%

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes

Swier

White

Johnson

et al. 2023

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

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On restricted approximation measures of Jacobi’s triple product

Leinonen,

Leinonen

2023

Ramanujan J

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We obtain rational approximations for Jacobi’s triple product $$\begin{aligned} \Pi _q(t):= \prod _{m=1}^\infty (1-q^{2m})(1+q^{2m-1}t)(1+q^{2m-1}t^{-1}), \end{aligned}$$ Π q ( t ) : = ∏ m = 1 ∞ ( 1 - q 2 m ) ( 1 + q 2 m - 1 t ) ( 1 + q 2 m - 1 t - 1 ) , when $$t=a/b\in {\mathbb {Q}}$$ t = a / b ∈ Q is non-zero and $$q=1/d$$ q = 1 / d with $$d\in {\mathbb {Z}}{\setminus }\{0, \pm 1 \}$$ d ∈ Z \ { 0 , ± 1 } . Especially we give effective and restricted approximation for the values of Jacobi’s triple product and for the values of Euler’s infinite product.

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On approximation measures of q-exponential function

Cited by 2 publications

References 8 publications

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes

On restricted approximation measures of Jacobi’s triple product

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