On and Under the Skin: Emerging Basidiomycetous Yeast Infections Caused by Trichosporon Species

Mariné, Marçal; Brown, Neil Andrew; Riaño-Pachón, Diego Mauricio; Goldman, Gustavo H.

doi:10.1371/journal.ppat.1004982

Cited by 48 publications

(53 citation statements)

References 62 publications

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“…Trichosporon species is increasingly recognized as a dangerous and opportunistic fungus in recent decades; however, pediatric cases remain uncommon . Among 16 reported species of Trichosporon , T. asahii is the most common cause of disseminated infections with little propensity for cutaneous disease .…”

Section: Discussionmentioning

confidence: 99%

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia

et al. 2018

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We report a case of disseminated Trichosporon asahii in a patient on systemic antifungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid‐Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture.

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Section: Discussionmentioning

confidence: 99%

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia

et al. 2018

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“…In SHP, the repeated exposure to airborne fungal antigens induces lung inflammation characterized by alveolitis and non-necrotizing granulomas. T. inkin, T. cutaneum, T. ovoides , and T. loubieri are also considered important agents in superficial trichosporonosis (Marine et al, 2015). …”

Section: Trichosporon Spp and Trichosporonosismentioning

confidence: 99%

“…Similar to other dimorphic fungi, and besides growing as a budding yeast, T. asahii is capable of filamentous growth, forming septate hyphae with abundant arthroconidia and blastoconidia (Marine et al, 2015). It can thrive in different host niches, including the skin, gut and oral mucosa, without causing disease.…”

Section: From a Commensal To A Pathogenic Lifestylementioning

confidence: 99%

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The Cell Biology of the Trichosporon-Host Interaction

Duarte-Oliveira

Rodrigues

Gonçalves

et al. 2017

Front. Cell. Infect. Microbiol.

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Fungi of the genus Trichosporon are increasingly recognized as causative agents of superficial and invasive fungal disease in humans. Although most species are considered commensals of the human skin and gastrointestinal tract, these basidiomycetes are an increasing cause of fungal disease among immunocompromised hosts, such as hematological patients and solid organ transplant recipients. The initiation of commensal or pathogenic programs by Trichosporon spp. involves the adaptation to the host microenvironment and its immune system. However, the exact virulence factors activated upon the transition to a pathogenic lifestyle, including the intricate biology of the cell wall, and how these interact with and subvert the host immune responses remain largely unknown. Here, we revisit our current understanding of the virulence attributes of Trichosporon spp., particularly T. asahii, and their interaction with the host immune system, and accommodate this knowledge within novel perspectives on fungal diagnostics and therapeutics.

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“…Recently, infections caused by non‐ C . albicans and other less‐common emerging yeast, such as species of Cryptococcus , Pichia , Rhodotorula , Trichosporon and Saccharomyces , have been widely reported . More than 100 yeast species have been identified as human pathogens and have been isolated from virtually all body sites .…”

Section: Introductionmentioning

confidence: 99%

Identification of three yeast species using the conventional and internal transcribed spacer region sequencing methods as first or second global record from human superficial infections

Abdel‐Sater

Moubasher

Soliman

2016

Mycoses

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During the mycological analysis of skin and nail samples taken from patients with onychomycosis and tineas in Assiut city, it is interesting to report that yeast fungi were the main causal agents being cultured from 45.79% of total cases. In general, 21 species of yeast were isolated. Some of these are reported for the first time from clinical specimens. From the literature available up-to-date around the world, this study reports for the first time Saccharomycopsis fibuligera as the causal agent of four clinical cases: two onychomycoses, one tinea capitis and one tinea amiantacea. Also, it is reported here the second record for Trichosporon dohaense from a case of onychomycosis of a 40-year-old woman (after its original description in 2009 by Taj-Aldeen et al. J Clin Microbiol 47: 1791). Candida galli was also reported for the first time from clinical specimen (tinea unguium) in 2014 by Galán-Sánchez et al. Mycopathol 178: 303, and this study reports the second case of onychomycosis by C. galli. These strains were identified on the basis of their phenotypic, biochemical, physiological and genotypic features. Strains and internal transcribed spacer (ITS) gene sequences of these species are deposited at Assiut University Mycological Center Culture Collection (AUMC) and National Center for Biotechnological Information (NCBI) respectively.

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On and Under the Skin: Emerging Basidiomycetous Yeast Infections Caused by Trichosporon Species

Cited by 48 publications

References 62 publications

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia

The Cell Biology of the Trichosporon-Host Interaction

Identification of three yeast species using the conventional and internal transcribed spacer region sequencing methods as first or second global record from human superficial infections

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