The frontiers of quantum electronics have been linked to the discovery of new refrigeration methods since the discovery of superconductivity at a temperature around 4 K, enabled by the liquefaction of helium. Presently, nanoelectronic devices typically reach electron temperatures around 10 mK to 100 mK by commercially available dilution refrigerators. This led to discoveries such as the quantum Hall effect and new technologies like superconducting and semiconductor quantum bits. However, cooling electrons via the encompassing lattice vibrations, or phonons, becomes inefficient at low temperatures. Further progress towards lower temperatures requires new cooling methods for electrons on the nanoscale, such as direct cooling with nuclear spins, which themselves can be brought to microkelvin temperatures by adiabatic demagnetization. Here, we introduce indium as a nuclear refrigerant for nanoelectronics and demonstrate that solely on-chip cooling of electrons is possible down to a record low temperature of 3.2 ± 0.1 mK in an unmodified dilution refrigerator.Quantum electronics relies on the precise control of electronic states in nanostructures, which is possible if the energy level separation is much higher than the thermal energy k B T . Thus, the efficient cooling of electrons is vital for solid state nanoelectronics and is an important design consideration for existing scalable quantum technologies. Access to novel states of matter such as electron-nuclear ferromagnets [1-3], non-Abelian anyons in fractional quantum Hall states [4,5], topological insulators [6] or exotic superconductivity [7-9] requires further progress in the cooling of nanoelectronics, approaching the µK regime.Typical electron temperatures of the order of 10 mK are accessible in semiconductor and metallic nanostructures by mounting the chip containing the devices on an insulating substrate cooled by commercially available dilution refrigerators. The lowest achievable electron temperature is limited by the heat transferred from the electrons at a temperature of T e to phonons at a temperature of T p . The heat flow between conduction electrons and phonons in a metallic volume V isQ ep = ΣV T 5 e order of 10 9 WK −5 m −3 [10,11]. A residual heat leak oḟ Q leak = 10 aW to a well-shielded nanostructure [12] with V = 1 µm 3 then yields T e ≈ 25 mK even as T p approaches zero. Increasing the coupling volume V by electrodeposition of thick metal films and improving thermalization by liquid helium immersion cells led to T e ≈ 4 mK [13][14][15] in specially built dilution refrigerators.The key to reduce the electron temperature further thus involves coupling the electron system to a cold bath without the necessity of heat transport via phonons. This can be achieved by nuclear magnetic cooling. In the limit of small Zeeman splitting compared to k B T n , the magnetization of the nuclear spin system is M ∝ B/T n at a magnetic field of B and a temperature of T n . T n can be reduced by adiabatically lowering the magnetic field from B i to B f . In the ab...