We consider a triple of N-functions (M, H, J ) that satisfy the -condition, μ = |x| α dx and suppose that an additive variant of interpolation inequality holds, R is an arbitrary set invariant with respect to external and internal dilations. We show that the above inequality implies its certain nonlinear variant involving the expressions R n H(|u|) μ(dx) and R n J (|∇ (2) u|) μ(dx). Various generalizations of this inequality to the more general class of N-functions, measures and to higher order derivatives are also discussed and the examples are presented.