By using Yang’s local fractional calculus theory, the method of weight function, and real-analysis techniques in the fractal set, a general Hilbert-type local fractional integral inequality with the kernel of a hyperbolic cosecant function is established. The necessary and sufficient condition for the constant factor of the general Hilbert-type local fractional integral inequality to be the best possible is discovered. Furthermore, two equivalent inequalities with the best constant factors were obtained.