In this work, we are concerned with the asymptotic properties of solutions for an impulsive neutral stochastic functional integro-differential equation. By applying the theory of resolvent operators, the Banach fixed point principle theorem, and results on stochastic analysis, we study respectively the existence, uniqueness, and global attracting and quasi-invariant sets of mild solutions for the considered equation. We also derive some sufficient conditions of pth moment exponential stability and almost surely exponential stability of the mild solutions. An example is provided in the end to illustrate the applications of the obtained results.