OmpR (TCS response regulator) of Aeromonas veronii plays a major role in drug resistance, stress resistance and virulence by regulating biofilm formation

Wang, Ying-da; Gong, Jin-shuo; Guan, Yong-chao; Zhao, Ze-lin; Cai, Yanan; Shan, Xiaofeng

doi:10.1016/j.micpath.2023.106176

Cited by 3 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the Δ ompR mutant was shown to exhibit reduced biofilm production as well. It was speculated that this increased antibiotic susceptibility may be due, in part, to the reduction in biofilm formation since biofilm typically impedes an antibiotic’s access to the bacteria (Wang et al 2023b ). Indeed, when 29 OMP knockout strains were created in A .…”

Section: Mechanisms Of Aeromonas -Associated Drug ...mentioning

confidence: 99%

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Neil,

Cheney,

Rosenzweig

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Aeromonas species (spp.) are well-known fish pathogens, several of which have been recognized as emerging human pathogens. The organism is capable of causing a wide spectrum of diseases in humans, ranging from gastroenteritis, wound infections, and septicemia to devastating necrotizing fasciitis. The systemic form of infection is often fatal, particularly in patients with underlying chronic diseases. Indeed, recent trends demonstrate rising numbers of hospital-acquired Aeromonas infections, especially in immuno-compromised individuals. Additionally, Aeromonas-associated antibiotic resistance is an increasing challenge in combating both fish and human infections. The acquisition of antibiotic resistance is related to Aeromonas’ innate transformative properties including its ability to share plasmids and integron-related gene cassettes between species and with the environment. As a result, alternatives to antibiotic treatments are desperately needed. In that vein, many treatments have been proposed and studied extensively in the fish-farming industry, including treatments that target Aeromonas quorum sensing. In this review, we discuss current strategies targeting quorum sensing inhibition and propose that such studies empower the development of novel chemotherapeutic approaches to combat drug-resistant Aeromonas spp. infections in humans. Key points • Aeromonas notoriously acquires and maintains antimicrobial resistance, making treatment options limited. • Quorum sensing is an essential virulence mechanism in Aeromonas infections. • Inhibiting quorum sensing can be an effective strategy in combating Aeromonas infections in animals and humans.

show abstract

Section: Mechanisms Of Aeromonas -Associated Drug ...mentioning

confidence: 99%