Omnipotent phosphorene: a next-generation, two-dimensional nanoplatform for multidisciplinary biomedical applications

Qiu, Meng; Ren, Wen Xiu; Jeong, Tae-Ho; Won, Miae; Park, Geun Young; Sang, David K.; Liu, Li Ping; Zhang, Han; Kim, Jong Seung

doi:10.1039/c8cs00342d

Cited by 372 publications

(216 citation statements)

References 52 publications

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“…The group V Xenes belong to semiconductors with tunable bandgaps, which endow them suitable for light‐absorption systems. Phosphorene and antimonene are two mostly studied photothermal agents in group V. However, the photothermal reports mainly focused on the biomedical field, i.e., photothermal cancer therapy, because of their excellent performance in photothermal conversion and photodegradability. There are only a few reports on phosphorene/antimonene‐based photothermal evaporation.…”

Section: Photothermal Evaporationmentioning

confidence: 99%

“…There are only a few reports on phosphorene/antimonene‐based photothermal evaporation. The efficient photothermal conversion makes them advantageous for photothermal evaporation, but their photo‐degradability should be considered for practical applications. There have been a vast number of strategies working on enhancing the stability of phosphorene, including covalent bonding via aryl diazonium, surface coordination of titanium sulfonate ligand, fluorination, alkali metal‐intercalation, metal‐ion passivation, and package by graphene shell, hexagonal BN, organic monolayers, graphene oxide (GO), AlO x , etc.…”

Section: Photothermal Evaporationmentioning

confidence: 99%

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Solar‐Inspired Water Purification Based on Emerging 2D Materials: Status and Challenges

et al. 2020

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Water shortage and the energy crisis are two major global challenges in this century. The solution for water crisis should be based on a sustainable energy source. Solar‐inspired water purification is an efficient and green technology for tackling the water challenge using abundant and clean solar energy through photothermal evaporation‐induced water production, photoinduced antimicrobial treatment, and photocatalytic degradation of organic contaminants. 2D nanomaterials draw significant attention for their use these three water‐purification methods because of their large surface area, broadband and strong absorption in the solar spectral range, and efficient photothermal and photocatalytic transformation. Herein, the recent development of 2D nanomaterials applied in photothermal evaporation, photoinduced antimicrobial treatment, and photocatalytic capability is comprehensively overviewed. Various strategies in enhancing the light‐absorption and light‐conversion efficiency for different 2D nanomaterials are presented. The challenges and perspectives of these 2D nanomaterials are further discussed for practical water purification. This Review highlights these green energy–driven water‐purification methods based on emerging 2D materials.

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Section: Photothermal Evaporationmentioning

confidence: 99%

Section: Photothermal Evaporationmentioning

confidence: 99%

Solar‐Inspired Water Purification Based on Emerging 2D Materials: Status and Challenges

et al. 2020

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“…Members of this new family include different chemical classes such as transition‐metal dichalcogenides (e.g., MoS 2 and WSe 2 ), transition metal carbides (MXenes, e.g., Ti 3 C 2 ), hexagonal boron nitride (hBN) and graphitic carbon nitride (g‐C 3 N 4 ) . These materials are not only finding numerous applications in electronics, optoelectronics, energy storage, sensors, and catalysis, but also hold great potential in the biomedical field, offering novel therapeutic avenues . Among 2D materials, g‐C 3 N 4 is a polymeric semiconductor material consisting of two of the most abundant elements, namely, C and N, as well as some peddle H atoms revealing a 2D/layered structure with a typical bandgap of 2.7 eV (454 nm) which can be excited with visible light .…”

Section: Introductionmentioning

confidence: 99%

Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy

Taheri

Ünal

Sevim

et al. 2020

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Thanks to its photocatalytic property, graphitic carbon nitride (g‐C3N4) is a promising candidate in various applications including nanomedicine. However, studies focusing on the suitability of g‐C3N4 for cancer therapy are very limited and possible underlying molecular mechanisms are unknown. Here, it is demonstrated that photoexcitation of g‐C3N4 can be used effectively in photodynamic therapy, without using any other carrier or additional photosensitizer. Upon light exposure, g‐C3N4 treatment kills cancer cells, without the need of any other nanosystem or chemotherapeutic drug. The material is efficiently taken up by tumor cells in vitro. The transcriptome and proteome of g‐C3N4 and light treated cells show activation in pathways related to both oxidative stress, cell death, and apoptosis which strongly suggests that only when combined with light exposure, g‐C3N4 is able to kill cancer cells. Systemic administration of the mesoporous form results in elimination from urinary bladder without any systemic toxicity. Administration of the material significantly decreases tumor volume when combined with local light treatment. This study paves the way for the future use of not only g‐C3N4 but also other 2D nanomaterials in cancer therapy.

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“…However, molecule or peptide‐based approaches have many drawbacks and limitations, including poor bioavailability and limited drug delivery. The nanomaterial‐based approach such as polymer nanoparticles (NPs), quantum dots, and antimonene/boron nanosheets have displayed great advantages including facile modification, excellent biocompatibility, and desirable biodegradability . In these designs, NPs have attracted much attention owing to their tunable physical/chemical properties.…”

Section: Introductionmentioning

confidence: 99%

Engineering Versatile Nanoparticles for Near‐Infrared Light‐Tunable Drug Release and Photothermal Degradation of Amyloid β

Lai

Zhu

et al. 2020

Adv Funct Materials

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Nanomedicines that inhibit/disassemble amyloid β (Aβ) aggregates in Alzheimer's disease (AD) are highly desirable yet remain challenging. Therapeutic efficacy and systemic delivery of reported molecules and nanoparticles (NPs) are hampered by various challenges, including low biocompatibility, off‐target toxicity, and lack of specificity. Herein, a versatile NP is designed by integrating high Aβ‐binding affinity, stimuli‐responsive drug release, and photothermal degradation properties for efficient disassembly of Aβ. Near‐infrared (NIR)‐absorbing conjugated polymer PDPP3T‐O14 serves as a photothermal core while thermal‐responsive polymer 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine at the outer layer as the NIR‐stimuli gatekeeper. Curcumin, an inhibitor of Aβ aggregation, is loaded into the NP with high encapsulation efficiency. The 5‐mer β‐sheet breaker peptides LPFFD (Leu‐Pro‐Phe‐Phe‐Asp) having high binding affinity toward Aβ are further anchored onto the surface of polyethylene glycol‐lipid shell for active Aβ‐targeting. The resultant NPs exhibit good Aβ‐targeting ability and obvious photothermal dissociation effect together with Aβ aggregation‐dependent fluorescence detection capability. Upon NIR laser irradiation, entrapped curcumin can be effectively released from the unconsolidated NPs to enhance the anti‐amyloid activity. In vitro studies demonstrate that the NPs dramatically lower Aβ‐induced cytotoxicity of PC12 cells, and therefore show great potential for the application in AD treatment.

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Omnipotent phosphorene: a next-generation, two-dimensional nanoplatform for multidisciplinary biomedical applications

Cited by 372 publications

References 52 publications

Solar‐Inspired Water Purification Based on Emerging 2D Materials: Status and Challenges

Solar‐Inspired Water Purification Based on Emerging 2D Materials: Status and Challenges

Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy

Engineering Versatile Nanoparticles for Near‐Infrared Light‐Tunable Drug Release and Photothermal Degradation of Amyloid β

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