Omission of Pepsin from Simulated Gastric Fluid in Evaluating Activated Charcoals as Antidotes

Daly, John S.; Cooney, David O.

doi:10.1002/jps.2600670846

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…The omission of pepsin from the incubation medium has been stated to have only a minor influence on the adsorption to charcoal (Daly & Cooney 1978). The use of SGF as the incubation medium instead of HCI had, however, a clear effect on the extent of aspirin adsorption when the amounts of unadsorbed fractions were compared.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ethanol and pH on the Adsorption of Drugs to Activated Charcoal: Studies in Vitro and in Man

Neuvonen

Olkkola

Alanen

1984

Acta Pharmacologica et Toxicologica

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The effect of ethanol on the adsorption of aspirin, quinidine and amitriptyline to activated charcoal was studied in vitro at pH 1.2 and 7.0. The adsorption of these drugs was greatly dependent on the charcoal-drug ratio and on the pH. Ethanol (10%) significantly (P<0.001) increased the percentage of their unadsorbed fraction at both pHs in vitro. In six healthy volunteers activated chiircoal (50 g), ingested 5 min. after aspirin (1000 mg) and quinidine sulfate (200 mg), reduced their bioavailability by about 70% (aspirin) and 99% (quinidine). A significant desorption of aspirin but not that of quinidine from charcoal was obvious on the second and third days and seemed to be related to the effect of pH. The absorption of' ethanol was not significantly prevented by charcoal. The concomitant ingestion of alcohol (50 g) with drugs antagonized only slightly the ability of charcoal to reduce the absorption of aspirin and quinidine.A'cy-words: Activated charcoalethanolaspirinquinidineamitriptylinein virroman

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Section: Discussionmentioning

confidence: 99%

Effect of Ethanol and pH on the Adsorption of Drugs to Activated Charcoal: Studies in Vitro and in Man

Neuvonen

Olkkola

Alanen

1984

Acta Pharmacologica et Toxicologica

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“…Daly and Cooney 4 have shown that the omission of pepsin from SGF has only a small effect on the in vitro adsorption of drugs.…”

Section: Methodsmentioning

confidence: 98%

Adsorption of Fluoxetine HCl by Activated Charcoal

Cooney

Thomason

1997

Journal of Pharmaceutical Sciences

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We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5). The data were fitted to both Langmuir and Freundlich equations. The Langmuir Qm values (maximal adsorption capacities) for pH 1.2 and 7.5 were 0.258 and 0.330 g drug/g charcoal, respectively. These excellent capacities suggest that oral charcoal therapy would be effective for fluoxetine overdose.

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In Vitro Coadsorption of Acetaminophen and N-Acetylcysteine onto Activated Carbon Powder

Rybolt

Burrell

Shults

et al. 1986

Journal of Pharmaceutical Sciences

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Omission of Pepsin from Simulated Gastric Fluid in Evaluating Activated Charcoals as Antidotes

Cited by 10 publications

References 12 publications

Effect of Ethanol and pH on the Adsorption of Drugs to Activated Charcoal: Studies in Vitro and in Man

Effect of Ethanol and pH on the Adsorption of Drugs to Activated Charcoal: Studies in Vitro and in Man

Adsorption of Fluoxetine HCl by Activated Charcoal

In Vitro Coadsorption of Acetaminophen and N-Acetylcysteine onto Activated Carbon Powder

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