Omiderm, a new synthetic wound covering: Physical properties and drug permeability studies

Abstract

Omiderm (Omikron Scientific Ltd., Rehovot, Israel), a new synthetic wound covering based on hydrophilized polyurethane, was found to be highly permeable to water. Values in the region of 5000 g/m2 24 h were found for the water permeability of Omiderm in comparison to 1400 and 500 g/m2 24 h for Biobrane (Hall, Woodroof Inc., Santa Ana, CA) and OP site (Smith and Nephew Ltd.), respectively. Permeabilities of antibacterial agents through Omiderm were found to be two to three orders of magnitude greater than those through Biobrane. The in vitro effectiveness of various antibacterial agents in lowering bacterial growth of different bacterial strains were applied to seeded agar plates through Omiderm membrane was investigated. NBH ointment (1% Neomycin, 1% Bacitracin, and 0.5% Hydrocortisone) was found to be the most effective material in inhibiting bacterial growth, except for Pseudomonas aeruginosa where silver sulfadiazine was superior. In in vivo experiments bacterial counts of infected wounds covered with Omiderm and topically treated with NBH were lowered to less than 10(3) organism/g tissue after one day of treatment.

The influence of preparation conditions on the characteristics of chitosan‐alginate dressings for skin lesions

“…The results obtained for water drainage ability indicated in Table I show that all membranes prepared had high water drainage abilities, with values of around 13 kg/m 2 day. As pointed out by Behar et al, 18 the average natural body liquid loss through normal skin is around 0.240 kg/m 2 day, while damaged surfaces have a higher liquid flow, varying between 3.4 and 5.2 kg/m 2 day, depending on the type of the lesion. Since permeability values of around 5 kg/m 2 day can be considered adequate for dressings to be used on lesions with high exudate production, 18 all membranes prepared can potentially be used on these kinds of wounds.…”

The use of a synthetic skin covering as a protective layer in the daily care of low birth weight infants

“…S. Hershkowitz moist. Omiderm is a thin, transparent film, permeable to gases, highly permeable to water vapor [1]; it prevents microbial invasion and is supplied sterile.…”

“…In order to overcome these difficulties we decided to test a new synthetic dressing, Omiderm, which until recently has been used mainly in the treatment of burns, chronic wounds, and skin ulcers [1,2,5].…”

Biodegradable Films in Trauma and Orthopedic Surgery

“…However, these occlusive dressings exhibit advantages such as pain reduction, impermeability for germs and elasticity [52,53]. Semiocclusive polyurethane (PU) films (Opsite ® , Omiderm ® , Tegaderm ® ) were widely used because of their unproblematic application and water vapour permeability [54][55][56][57][58]. In superficial wounds, a significantly faster keratinocyte proliferation could be proven than with the open wound treatment [59][60][61][62], and the wound exudate under the covers showed a high lysozyme concentration and a large number of neutrophile granulozytes with bactericidal effectiveness was found [63].…”