'Omics' and endocrine-disrupting chemicals — new paths forward

Messerlian, Carmen; Martinez, Rosie M.; Hauser, Russ; Baccarelli, Andrea A.

doi:10.1038/nrendo.2017.81

Cited by 50 publications

(28 citation statements)

References 79 publications

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“…Recent advances in the field of omics will be of great advantage for MDC research. For instance, the use of mitochondriomics technology, which is the study of the properties of mitochondrial DNA, has been suggested to identify molecular 'fingerprints' in MDC research (Messerlian et al 2017). Application of mitochondriomics along with other omics technologies (e.g.…”

Section: Discussionmentioning

confidence: 99%

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

Marroquí

Tudurí

Alonso-Magdalena

et al. 2018

Journal of Endocrinology

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Type 2 diabetes is a chronic, heterogeneous syndrome characterized by insulin resistance and pancreatic β-cell dysfunction or death. Among several environmental factors contributing to type 2 diabetes development, endocrine-disrupting chemicals (EDCs) have been receiving special attention. These chemicals include a wide variety of pollutants, from components of plastic to pesticides, with the ability to modulate endocrine system function. EDCs can affect multiple cellular processes, including some related to energy production and utilization, leading to alterations in energy homeostasis. Mitochondria are primarily implicated in cellular energy conversion, although they also participate in other processes, such as hormone secretion and apoptosis. In fact, due to mitochondria involvement in so many crucial cellular processes in metabolic relevant tissues, mitochondrial dysfunction has been linked to different metabolic diseases, including insulin resistance and type 2 diabetes. Herein, we review the main mechanisms whereby metabolism-disrupting chemical (MDC), a subclass of EDCs that disturbs energy homeostasis, cause mitochondrial dysfunction, thus contributing to the establishment of insulin resistance and type 2 diabetes. We conclude that MDC-induced mitochondrial dysfunction, which is mainly characterized by perturbations in mitochondrial bioenergetics, biogenesis, and dynamics, excessive reactive oxygen species production, and activation of the mitochondrial pathway of apoptosis, seems to be a relevant mechanism linking MDCs to type 2 diabetes development.

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Section: Discussionmentioning

confidence: 99%

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

Marroquí

Tudurí

Alonso-Magdalena

et al. 2018

Journal of Endocrinology

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“…Another interesting concept is to generate fingerprints of exposure to environmental toxicants using evolving -omics technologies (Messerlian et al 2017) and apply these signatures as biomarkers and predictors of response. An important step toward this is to establish robust and universally recognized epimutation signatures, analogous to the mutational signatures established by genome sequencing (Kucab et al 2019).…”

Section: Perspectives For the Future Of The Fieldmentioning

confidence: 99%

The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome

Chung

Herceg

2020

Environ Health Perspect

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BACKGROUND: It has been estimated that a substantial portion of chronic and noncommunicable diseases can be caused or exacerbated by exposure to environmental chemicals. Multiple lines of evidence indicate that early life exposure to environmental chemicals at relatively low concentrations could have lasting effects on individual and population health. Although the potential adverse effects of environmental chemicals are known to the scientific community, regulatory agencies, and the public, little is known about the mechanistic basis by which these chemicals can induce long-term or transgenerational effects. To address this question, epigenetic mechanisms have emerged as the potential link between genetic and environmental factors of health and disease. OBJECTIVES: We present an overview of epigenetic regulation and a summary of reported evidence of environmental toxicants as epigenetic disruptors. We also discuss the advantages and challenges of using epigenetic biomarkers as an indicator of toxicant exposure, using measures that can be taken to improve risk assessment, and our perspectives on the future role of epigenetics in toxicology. DISCUSSION: Until recently, efforts to apply epigenomic data in toxicology and risk assessment were restricted by an incomplete understanding of epigenomic variability across tissue types and populations. This is poised to change with the development of new tools and concerted efforts by researchers across disciplines that have led to a better understanding of epigenetic mechanisms and comprehensive maps of epigenomic variation. With the foundations now in place, we foresee that unprecedented advancements will take place in the field in the coming years.

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“…Metabolic diseases are often associated with mitochondrial dysfunction [26]. Therefore, it is not surprising that several MDCs have been shown to modulate processes involved in fatty acid and glucose metabolism including the production and utilization of energy in mitochondria [27,28] (Table 1). MDCs may interfere with these processes either by directly interacting with mitochondrial proteins or secondarily by inducing transcriptional changes in genes coding for these proteins.…”

Section: Introductionmentioning

confidence: 99%

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

Küblbeck

Vuorio

Niskanen

et al. 2020

IJMS

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Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an increasing health concern worldwide. However, while epidemiological and experimental data on the close association of EDs and adverse metabolic effects are mounting, predictive methods and models to evaluate the detailed mechanisms and pathways behind these observed effects are lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project brings together systems toxicologists; experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate (pre)validated test methods to assess the metabolic effects of Eds, and to predict emergent adverse biological phenotypes by following the adverse outcome pathway (AOP) paradigm.

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'Omics' and endocrine-disrupting chemicals — new paths forward

Cited by 50 publications

References 79 publications

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

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