Omicron Wave Modification of the Coronavirus Disease 2019 Paradigm in Children With Cystic Fibrosis

Thouvenin, Guillaume; Prévost, Bertrand; Corvol, Harriet

doi:10.1093/infdis/jiac328

Cited by 4 publications

(9 citation statements)

References 10 publications

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“…This variant showed to be more contagious but led to milder illness forms of SARS‐CoV‐2 pediatric infection 28 . Thouvenin et al 29 studied the impact of the Omicron variant and compared with previous data in cwCF. They found an increase from 9% to 32% in SARS‐CoV‐2 infections in their cwCF cohort ( n = 76) during the Omicron wave.…”

Section: Discussionmentioning

confidence: 99%

SARS‐CoV‐2 infection in children with cystic fibrosis: A cross‐sectional multicenter study in Spain. New waves, new knowledge

Mondejar‐Lopez,

Moreno‐Galarraga,

de Manuel‐Gomez

et al. 2023

Pediatric Pulmonology

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IntroductionThe association between viral infections and pulmonary exacerbations in children with cystic fibrosis (cwCF) is well established. However, the question of whether cwCF are at a higher risk of COVID‐19 or its adverse consequences remains controversial.MethodsWe conducted an observational, multicenter, cross‐sectional study of cwCF infected by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) between March 2020 and June 2022, (first to sixth COVID‐19 pandemic waves) in Spain. The study aimed to describe patients' basal characteristics, SARS‐CoV‐2 clinical manifestations and outcomes, and whether there were differences across the pandemic waves.ResultsDuring study time, 351 SARS‐CoV2 infections were reported among 341 cwCF. Median age was 8.5 years (range 0–17) and 51% were female. Cases were unevenly distributed across the pandemic, with most cases (82%) clustered between November 2021 and June 2022 (sixth wave, also known as Omicron Wave due to the higher prevalence of this strain in that period in Spain). Most cwCF were asymptomatic (24.8%) or presented with mild Covid‐19 symptoms (72.9%). Among symptomatic, most prevalent symptoms were fever (62%) and increased cough (53%). Infection occurring along the sixth wave was the only independent risk factor for being symptomatic. Just eight cwCF needed hospital admission. No multisystem inflammatory syndrome, persisting symptoms, long‐term sequelae, or deaths were reported.ConclusionsSpanish current data indicate that cwCF do not experience higher risks of SARS‐CoV‐2 infection nor worse health outcomes or sequelae. Changes in patients' basal characteristics, clinical courses, and outcomes were detected across waves. While the pandemic continues, a worldwide monitoring of COVID‐19 in pediatric CF patients is needed.

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Section: Discussionmentioning

confidence: 99%

SARS‐CoV‐2 infection in children with cystic fibrosis: A cross‐sectional multicenter study in Spain. New waves, new knowledge

Mondejar‐Lopez,

Moreno‐Galarraga,

de Manuel‐Gomez

et al. 2023

Pediatric Pulmonology

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“… 5 , 6 , 7 This has caused the recrudescence of severe COVID‐19 forms and hospitalizations in children, particularly in the age group of 0–9 years because of the limited vaccination coverage in this population. 7 , 8 , 9 , 10 …”

Section: Pediatric Epidemiology Of Sars‐cov‐2mentioning

confidence: 99%

“…Most children with CF who were diagnosed as infected by SARS‐CoV‐2 during the first COVID wave remained asymptomatic; the diagnosis was confirmed by a systematic assessment of SARS‐CoV‐2 serology or by SARS‐CoV‐2 RT‐PCR performed in case of contact. 10 …”

Section: Focus On Atypical Respiratory Manifestations Of Covid‐19 In ...mentioning

confidence: 99%

“…In late 2021–early 2022, a resurgence of cases in young adults and children was observed with the delta and omicron variants in France 5–7 . This has caused the recrudescence of severe COVID‐19 forms and hospitalizations in children, particularly in the age group of 0–9 years because of the limited vaccination coverage in this population 7–10 …”

Section: Pediatric Epidemiology Of Sars‐cov‐2mentioning

confidence: 99%

“…50 or by SARS-CoV-2 RT-PCR performed in case of contact. 10 It is still difficult to estimate the true susceptibility of pwCF to SARS-CoV-2 infection. Indeed, they are used in barrier gestures, such as wearing masks, frequent hand washing, and social distancing, to limit exposure and avoid infection.…”

Section: Children With Sickle Cell Diseasementioning

confidence: 99%

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COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

Corvol

Prévost

Aubertin

et al. 2022

Pediatric Pulmonology

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The coronavirus disease 2019 (COVID‐19) outbreak has evolved with different waves corresponding to subsequent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mutations. While the most severe cases have been observed in the elderly and in individuals with underlying comorbidities, severe pediatric and young adult cases have been observed, as well as post‐infectious inflammatory syndromes and persistent symptoms leading to long‐COVID. This manuscript describes the experience of a pediatric respiratory unit during the first year of the pandemic and reviews the corresponding literature with a special emphasis on children and young people with underlying conditions, such as immunosuppression, sickle cell disease, and cystic fibrosis.

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Course of Coronavirus Infection in a Child With Cystic Fibrosis

Chirkova¹,

Ledyakina²,

Ruzavina³

et al. 2023

IJAFR (МЖПФИ)

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В статье приведен клинический случай заболевания коронавирусной инфекцией у ребенка с муковисцидозом. Отражены принципы диагностики и комплексного лечения сочетанной патологии у ребенка. На данный момент известно, что тяжелая форма COVID-19 у детей встречается реже, чем у взрослых. Однако дети подвержены, по крайней мере, двум долгосрочным последствиям: мультисистемному воспалительному синдрому и длительному постковидному синдрому. Дети с муковисцидозом считаются клинически уязвимой группой населения с присущим им более высоким риском развития тяжелой формы COVID-19, хотя некоторыми исследователями была отмечена определенная вариабельность в отношении исходов и госпитализации. Согласно статистическим данным, общее число всех пациентов с муковисцидозом в Республике Мордовия на 2020 год в абсолютных числах составляет 20 человек, количество взрослых в абсолютных цифрах -5 человек. Доля больных в федеральном округе -2,6%; доля в общем регистре -0,5%. Коронавирусная инфекция, белково-энергетическая недостаточность, токсическое поражение печени явились теми патологиями, которые осложнили течение основного заболевания в иммуннокомпромиссном организме ребенка. В данном случае детская смерть не предотвратима, учитывая наличие муковисцидоза, коронавирусной инфекции и тяжелой дыхательной недостаточности, развившейся в результате данных заболеваний, которые сыграли ведущую роль в танатогенезе у ребенка.

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Omicron Wave Modification of the Coronavirus Disease 2019 Paradigm in Children With Cystic Fibrosis

Cited by 4 publications

References 10 publications

SARS‐CoV‐2 infection in children with cystic fibrosis: A cross‐sectional multicenter study in Spain. New waves, new knowledge

SARS‐CoV‐2 infection in children with cystic fibrosis: A cross‐sectional multicenter study in Spain. New waves, new knowledge

COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

Course of Coronavirus Infection in a Child With Cystic Fibrosis

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