Omicron variant infection and the associated immunological scenario

Mukherjee, Anirban Goutam; Wanjari, Uddesh Ramesh; Murali, Reshma; Chaudhary, Uma; Renu, Kaviyarasi; Madhyastha, Harishkumar; Iyer, Mahalaxmi; Vellingiri, Balachandar; Gopalakrishnan, Abilash Valsala

doi:10.1016/j.imbio.2022.152222

Cited by 14 publications

(12 citation statements)

References 49 publications

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“…By attaching to the viral surface, the antibodies inhibit infection. However, because of the second line of protection offered by vaccinations, where T and B cells act after the infection begins, Omicron may not lead to severe illness in the vaccinated individuals [124 ] . The ability of antibodies to protect upper respiratory tract infections may wane over time or owing to spike protein mutations.…”

Section: Mutational Changes and Their Impactsmentioning

confidence: 99%

“…The vaccinations, on the other hand, give the second line of defense against the infection caused by the Omicron variant [125 ] . Considering how swiftly the T and B cells operate, one can possibly stay asymptomatic [31] , [124] . Omicron contains various novel mutations in the RBD of the S-protein that dramatically increase binding affinity in the RBDhACE2 complex while also evolving and rapidly spreading in humans all over the world [126 ] .…”

Section: Mutational Changes and Their Impactsmentioning

confidence: 99%

“…Omicron contains various novel mutations in the RBD of the S-protein that dramatically increase binding affinity in the RBDhACE2 complex while also evolving and rapidly spreading in humans all over the world [126 ] . It may have provided an advantage to the ancient SARS-CoV-2 and previous VOCs in lung cells and primary human airway epithelial cells by permitting spike activation by the plasma membrane protease TMPRSS2, allowing for fast cell surface fusion [124] , [127] . Recently, Saxena et al (2022) reported that the dynamic transmission of Omicron appears to be stronger than that of previous SARS-CoV-2's strains.…”

Section: Mutational Changes and Their Impactsmentioning

confidence: 99%

See 2 more Smart Citations

Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?

Dhawan

Saied

Mitra

et al. 2022

Biomedicine & Pharmacotherapy

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Section: Mutational Changes and Their Impactsmentioning

confidence: 99%

Section: Mutational Changes and Their Impactsmentioning

confidence: 99%

Section: Mutational Changes and Their Impactsmentioning

confidence: 99%

See 1 more Smart Citation

Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?

Dhawan

Saied

Mitra

et al. 2022

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

“…Additionally, the number of new deaths has also decreased, with 81,000 new deaths reported in the week of 7 February, down 10% from the prior week [290]. The UK Health Security Agency classified the variants BA.4 and BA.5 as Omicron lineage variants [292]. The first incidence of the BA.4 variant was reported in South Africa in January 2022.…”

Section: Omicronmentioning

confidence: 99%

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

Hoteit

Yassine

2022

Vaccines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide. Several vaccines have been produced and tested over the last two years. The SARS-CoV-2 virus, on the other hand, has mutated over time, resulting in genetic variation in the population of circulating variants during the COVID-19 pandemic. It has also shown immune-evading characteristics, suggesting that vaccinations against these variants could be potentially ineffective. The purpose of this review article is to investigate the key variants of concern (VOCs) and mutations of the virus driving the current pandemic, as well as to explore the transmission rates of SARS-CoV-2 VOCs in relation to epidemiological factors and to compare the virus’s transmission rate to that of prior coronaviruses. We examined and provided key information on SARS-CoV-2 VOCs in this study, including their transmissibility, infectivity rate, disease severity, affinity for angiotensin-converting enzyme 2 (ACE2) receptors, viral load, reproduction number, vaccination effectiveness, and vaccine breakthrough.

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“…The most recent SARS-CoV-2 variants have accumulated many mutations on the spike protein. Thus, since the vaccines have been developed on the wild-type version of spike, many cases of reinfection by COVID-19 and infections in vaccinated people have been observed [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Structural and Phylogenetic Analysis of SARS-CoV-2 Spike Glycoprotein from the Most Widespread Variants

Caputo

Mandrich²

2022

Life

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The SARS-CoV-2 pandemic, reported for the first time at the end of 2019 in the city of Wuhan (China), has spread worldwide in three years; it lead to the infection of more than 500 million people and about six million dead. SARS-CoV-2 has proved to be very dangerous for human health. Therefore, several efforts have been made in studying this virus. In a short time, about one year, the mechanisms of SARS-CoV-2 infection and duplication and its physiological effect on human have been pointed out. Moreover, different vaccines against it have been developed and commercialized. To date, more than 11 billion doses have been inoculated all over the world. Since the beginning of the pandemic, SARS-CoV-2 has evolved; it has done so by accumulating mutations in the genome, generating new virus versions showing different characteristics, and which have replaced the pre-existing variants. In general, it has been observed that the new variants show an increased infectivity and cause milder symptoms. The latest isolated Omicron variants contain more than 50 mutations in the whole genome and show an infectivity 10-folds higher compared to the wild-type strain. Here, we analyse the SARS-CoV-2 variants from a phylogenetic point of view and hypothesize a future scenario for SARS-CoV-2, by following its evolution to date.

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Omicron variant infection and the associated immunological scenario

Cited by 14 publications

References 49 publications

Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?

Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

Structural and Phylogenetic Analysis of SARS-CoV-2 Spike Glycoprotein from the Most Widespread Variants

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