2021
DOI: 10.1038/d41586-021-03824-5
|View full text |Cite
|
Sign up to set email alerts
|

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Abstract: This is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

11
194
1

Year Published

2021
2021
2022
2022

Publication Types

Select...
5
2

Relationship

1
6

Authors

Journals

citations
Cited by 234 publications
(234 citation statements)
references
References 21 publications
11
194
1
Order By: Relevance
“…We isolated Omicron virus without the R346K mutation from an infection in South Africa. This virus had similar neutralization escape (Fig S1 ) as a previous Omicron isolate with the R346K mutation 1 . We neutralized this isolate with plasma from the blood of 15 participants enrolled during the Omicron infection wave in South Africa, with each participant having a confirmed diagnosis of SARS-CoV-2 by qPCR.…”
mentioning
confidence: 54%
See 2 more Smart Citations
“…We isolated Omicron virus without the R346K mutation from an infection in South Africa. This virus had similar neutralization escape (Fig S1 ) as a previous Omicron isolate with the R346K mutation 1 . We neutralized this isolate with plasma from the blood of 15 participants enrolled during the Omicron infection wave in South Africa, with each participant having a confirmed diagnosis of SARS-CoV-2 by qPCR.…”
mentioning
confidence: 54%
“…(https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/fil e/1043807/technical-briefing-33.pdf). In South Africa Omicron infections led to a lower incidence of severe disease relative to other variants 8 , although this can be at least partly explained by pre-existing immunity 1 . While Omicron infections are rising steeply, many countries still have high levels of infection with the Delta variant.…”
mentioning
confidence: 96%
See 1 more Smart Citation
“…While for Delta S trimer, our recent work showed the open-transition ratio is 75.3%-24.7%, indicating the conformational masking mechanism may be less effective for the Delta variant 32,36 . This could contribute greatly to the striking immune evasion of the Omicron variant 15,[17][18][19][20][21][22] .…”
Section: Discussionmentioning
confidence: 99%
“…Recently, a new variant, named Omicron (B.1.1.529), was first reported in South Africa in November 2021 and classified as the fifth VOC by the World Health Organization (WHO) on 26 November 2021. Omicron exhibits a high transmission rate (R0>3) 12,13 , and, as of 22 December 2021, it has spread into 110 countries 14 .…”
Section: Introductionmentioning
confidence: 99%