OmicLoupe: Facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons

Abstract

Visual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data and reveal biological trends. The OmicLoupe software was developed to facilitate such exploration and provides more than 15 interactive cross-dataset visualizations for omic data. It expands visualizations to multiple datasets for quality control, statistical comparisons and overlap and correlation analyses, while allowing for rapid inspection and downloading of selected features. The usage of OmicLoupe is demonstrated in three diverse studies, including an analysis of SARS-CoV-2 infection across omic layers, based on previously published proteomics and transcriptomics studies. OmicLoupe is available at quantitativeproteomics.org/omicloupe .

OmicLoupe: facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons

“…It provides the ability to explore up to two datasets, and provides comparative views between statistical contrasts performed either within one dataset or across multiple. It is organized in modules allowing rapidly shifting from a sample-wide view, to inspect individual statistical comparisons, overlaps between multiple comparisons, to understanding single features (Adapted from schematics shown at OmicLoupe's home page [36])…”