Omeprazole-induced drug reaction with eosinophilia and systemic symptoms (DRESS)

Bourneau‐Martin, Delphine; Leclech, C; Jamet, A.; Drablier, Guillaume; Trenque, Thierry; Juengel, Kerry; Heath, Drew; Lagarce, Laurence; Lainé-Cessac, Pascale

doi:10.1684/ejd.2014.2343

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…Nine cutaneous reactions associated with RYR products were collected. Most of them (42,(44)(45)(46)(47) occurred with a 1-4-day latency, the others occurred after 10 days (48), 3 weeks (5) or about 2 months (48) of treatment. Four cases (41, 43, 45 and 48) were serious and required hospitalization.…”

Section: Case-by-case Assessmentmentioning

confidence: 99%

“…Laboratory tests suggested that the patient had a Herpes simples virus infection, a condition associated with DRESS [45]. Cases of DRESS are described also for atorvastatine [46], a lipid-lowering drug belonging to the statins class (as monacolin contained in RYR), as well as for omeprazole [47], a proton pump inhibitor similar to pantoprazole that the patient was consuming. Based on these considerations, the causality between DRESS and RYR preparation was judged as possible.…”

Section: Case-by-case Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Mazzanti

Moro

Raschi

et al. 2017

Brit J Clinical Pharma

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Section: Case-by-case Assessmentmentioning

confidence: 99%

Section: Case-by-case Assessmentmentioning

confidence: 99%

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Mazzanti

Moro

Raschi

et al. 2017

Brit J Clinical Pharma

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“…A higher risk of hypersensitive reactions could be expected when other drugs with the structure of substituted benzimidazoles (e.g., anthelmintics, H1 antihistamines) are co-administered. The immediate (urticarial/angioedema, anaphylaxis) and delayed hypersensitive reactions (Drug Reaction with Eosinophilia and Systemic Symptoms, Steven-Johnson syndrome/toxic epidermal necrolysis) are reported as severe adverse events associated with PPI therapy that can develop even after short-term use (47)(48)(49)(50)(51)(52)(53). Reports of more severe adverse effects including kidney disease, fractures, infections and vitamin deficiencies are very rare and are generally associated with long-term use (54,55).…”

Section: Discussionmentioning

confidence: 99%

CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal

et al. 2022

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To this date, there are no recommendations for personalized stress ulcer prophylaxis (SUP) in critical care that would take the patient's individual genetic predispositions into account. Of drugs used for this purpose, proton pump inhibitors (PPIs) are the first-choice drugs in intensive care unit patients. The degradation of proton pump inhibitors is mediated by cytochrome P450 (CYP) enzymes; in particular, CYP2C19 and, to a lesser extent, CYP3A4 are involved. Expression and metabolic activity of, namely in, CYP2C19 is significantly affected by single nucleotide polymorphisms, the drug metabolization rate varies greatly from ultrarapid to poor and likely influences the optimal dosage. As these CYP2C19 predictive phenotypes via CYP2C19 haplogenotypes (rs12248560/rs4244285) can be relatively easily determined using the current standard equipment of hospital laboratories, we prepared a set of recommendations for personalized PPI-based stress ulcer prophylaxis taking into account the patient's CYP2C19 predictive phenotype determined in this way. These recommendations are valid, in particular, for European, American and African populations, because these populations have the high representations of the CYP2C19*17 allele associated with the overexpression of the CYP2C19 gene and ultrarapid degradation of PPIs. We propose the CYP2C19 gene profiling as a tool for personalized SUP with PPI in critically ill patients.

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“…Most patients with PPI-induced DRESS can achieve a good prognosis if confirmation of the diagnosis, discontinuation of the PPI, and initiation of glucocorticoid-based therapy are performed in a timely manner. [ 11 ] However, the early diagnosis and treatment of PPI-induced DRESS requires a multidisciplinary approach. The present case highlights the need for clinicians to remain on high alert for potential life-threatening complications when prescribing PPIs.…”

Section: Discussionmentioning

confidence: 99%

Drug rash with eosinophilia and systemic symptoms and severe renal injury induced by proton pump inhibitor therapy

He¹,

Ying²,

Fei³

et al. 2020

Medicine

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Introduction: Proton pump inhibitors (PPIs) are widely prescribed and generally well tolerated but can rarely cause severe allergic reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS). We report a case of DRESS and renal injury induced by PPIs, and describe the therapeutic process. Patient concerns: The patient was a 66-year-old female who complained of fever, pruritus, desquamation, erythema multiforme, and anuria caused by omeprazole taken for 2 weeks to treat abdominal distention. Diagnosis: The clinical history revealed a similar episode of PPI-induced fever, eosinophilia, and acute kidney injury more than 1 year ago. The present laboratory tests revealed eosinophilia and oliguric renal failure. The renal biopsy was performed subsequently and proved the diagnosis of PPI-induced DRESS. Interventions: After the suspected diagnosis of PPI-induced DRESS, omeprazole was discontinued and methylprednisolone infusion (40 mg qd) was initiated. Because of oliguric renal failure, the patient received intermittent hemodialysis. Outcomes: The patient initially responded to omeprazole discontinuation, hemodialysis, and glucocorticoids but later died from severe infection during the tapering of glucocorticoid therapy. Conclusion: Clinicians should remain on high alert for potential life-threatening complications when prescribing PPIs. If unexplained renal injury develops in a patient taking a PPI, renal biopsy may help in identifying the pathogenesis and might facilitate timely intervention.

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Omeprazole-induced drug reaction with eosinophilia and systemic symptoms (DRESS)

Cited by 15 publications

References 5 publications

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system

CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal

Drug rash with eosinophilia and systemic symptoms and severe renal injury induced by proton pump inhibitor therapy

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