Omeprazole, Helicobacter pylori status, and alterations in the intragastric milieu facilitating bacterial N-nitrosation

Mowat, Craig; Williams, Craig; Gillen, Derek; Hossack, M.; Gilmour, Denise; Carswell, Anne; Wirz, Angela A.; Preston, Tom; McColl, Kenneth E.L.

doi:10.1053/gast.2000.9367

Cited by 145 publications

(113 citation statements)

References 39 publications

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“…Bacterial populations in other parts of the digestive system, including the oral cavity and colon, play important roles in the maintenance of local physiology as well as in disease etiology (1)(2)(3)(4)(5)(6)(7)33). A full assessment of the composition, transience, or stability of this complex bacterial biota in the distal esophagus and associations with disease remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…2). These SLOTU included Streptococcus mitis (169), Streptococcus thermophilus (100), Streptococcus parasanguis (67), Veillonella atypica (66), Veillonella dispar (62), Rothia mucilaginosus (20), Megasphaera micronuciformis (19), Granulicatella adiacens (15), Prevotella pallens (14), Bacteroides AF385513 (11), TM7 AF385520 (11), Clostridium AY278618 (10), Bulleidia moorei (5), and Actinomyces odontolyticus (5). Variation also was observed, because, for example, Prevotella veroralis, the sixth most abundant SLOTU detected (5.0%), was not detected in case D (Fig.…”

Section: Microscopic Examination Of Bacterial Biota In the Distal Esomentioning

confidence: 99%

“…Conversely, loss of normal biota is responsible for overgrowth of opportunistic pathogens that normally are inhibited, such as occurs in antibiotic-associated colitis (3). Microenvironment alterations may favor overgrowth of bacteria that produce carcinogenic metabolites (4,5), promoting tumorigenesis in inflammation-induced cancers, such as adenocarcinoma in mouse experimental colitis models (6).…”

mentioning

confidence: 99%

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Bacterial biota in the human distal esophagus

Pei

Bini²,

Yang³

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

413

314

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The esophagus, like other luminal organs of the digestive system, provides a potential environment for bacterial colonization, but little is known about the presence of a bacterial biota or its nature. By using broad-range 16S rDNA PCR, biopsies were examined from the normal esophagus of four human adults. The 900 PCR products cloned represented 833 unique sequences belonging to 41 genera, or 95 species-level operational taxonomic units (SLOTU); 59 SLOTU were homologous with culture-defined bacterial species, 34 with 16S rDNA clones, and two were not homologous with any known bacterial 16S rDNA. Members of six phyla, Firmicutes, Bacteroides, Actinobacteria, Proteobacteria, Fusobacteria, and TM7, were represented. A large majority of clones belong to 13 of the 41 genera (783͞900, 87%), or 14 SLOTU (574͞900, 64%) that were shared by all four persons. Streptococcus (39%), Prevotella (17%), and Veilonella (14%) were most prevalent. The present study identified Ϸ56 -79% of SLOTU in this bacterial ecosystem. Most SLOTU of esophageal biota are similar or identical to residents of the upstream oral biota, but the major distinction is that a large majority (82%) of the esophageal bacteria are known and cultivable. These findings provide evidence for a complex but conserved bacterial population in the normal distal esophagus.

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Section: Discussionmentioning

confidence: 99%

Section: Microscopic Examination Of Bacterial Biota In the Distal Esomentioning

confidence: 99%

mentioning

confidence: 99%

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Bacterial biota in the human distal esophagus

Pei

Bini²,

Yang³

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

413

314

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“…[71][72][73] Whether gastric cancer is prevented by eradication of H pylori is still highly uncertain, 243 but some have advocated prophylactic anti-H pylori treatment for patients on long term acid suppressive therapy as these patients may be at increased risk of developing gastric cancer. [244][245][246] This issue is still debated 247 248 but it may support H pylori eradication in dyspeptic patients.…”

Section: Rationale and Limitations Of The Various Approaches Of The Dmentioning

confidence: 99%

A rational approach to uninvestigated dyspepsia in primary care: review of the literature

Arents

Thijs

Kleibeuker

2002

Postgraduate Medical Journal

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In this paper the rationale and limitations of the four most important approach strategies to dyspepsia in primary care (empiric treatment, prompt endoscopy, “test-and-scope”, and “test-and-treat”) are analysed. It is concluded that in the absence of alarm symptoms, a “test-and-treat” approach is currently the most rational approach provided that three conditions are met: (1) a highly accurate test should be used, (2) the prevalence of Helicobacter pylori in the population should not be too low, and (3) an effective anti-H pylori regimen should be prescribed taking sufficient time to instruct and motivate the patient.

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“…Reduced colonization may be due to insufficient gastric acid to counterbalance the ammonia produced by the organism. Moreover, with a rise in pH, the stomach is at risk of colonization by less fastidious bacterial species, which may then out-compete H. pylori (20,21). Thus, in the end, H. pylori may merely be the trigger for a cascade of events that is sustained by the immune system and by repopulation of the stomach by organisms other than H. pylori.…”

mentioning

confidence: 99%

VacA pores as portable portals for urea

Merchant

2001

J. Clin. Invest.

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Omeprazole, Helicobacter pylori status, and alterations in the intragastric milieu facilitating bacterial N-nitrosation

Cited by 145 publications

References 39 publications

Bacterial biota in the human distal esophagus

Bacterial biota in the human distal esophagus

A rational approach to uninvestigated dyspepsia in primary care: review of the literature

VacA pores as portable portals for urea

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