Omeprazole for the treatment of posterior laryngitis

Kamel, Perry L.; Hanson, David G.; Kahrilas, Peter J.

doi:10.1016/0002-9343(94)90061-2

Cited by 180 publications

(106 citation statements)

References 11 publications

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“…Empirical treatment for patients without typical symptoms or objective evidence of GERD thus cannot be routinely recommended. Th e historic recommendation is to treat patients with higher dose PPI (twice daily) than patients with typical GERD symptoms; however, this is based on uncontrolled and observational data only ( 143,144 ). Patients who are treated with PPI and who do not respond to a 2 -3 month course of acid suppression can be evaluated and managed as proposed in the " refractory GERD " section.…”

Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,529

1,430

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Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,529

1,430

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“…7 Typical GERD-related symptoms (heartburn and regurgitation) are absent in the majority of patients with chronic laryngitis, and the presence of esophageal inflammation ranges from 19% to 40% in these patients. 70,71 Abnormal esophageal pH monitoring was found in 55-79% and 18-70% of patients with chronic hoarseness or posterior laryngitis, respectively.…”

Section: Extraesophageal M Anifestations Of Gastroesophageal Reflux Dmentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

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“…This is in accordance with several previously published studies [1±7, 10, 14±19] in which GOR-related chronic cough was relieved with medical antireflux therapy. Unfortunately most of these 10,14,15] or they have been retrospective [16,17]. There is also evidence that operative treatment of GOR will improve chronic cough [27,28].…”

Section: Discussionmentioning

confidence: 99%

Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole

Kiljander¹,

Salomaa²,

Hietanen³

et al. 2000

Eur Respir J

137

105

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Gastro-oesophageal reflux (GOR) is an important cause of chronic cough. There has been a lack of placebo-controlled trials treating GOR related chronic cough with antireflux therapy. The aim of this study was to determine the efficacy of omeprazole on GOR related chronic cough.After excluding other common causes of cough, oesophageal pH monitoring was performed on 48 patients with chronic cough. Twenty-nine patients found to have GOR were randomized in a double-blind fashion to receive omeprazole 40 mg o.d. or placebo for 8 weeks. After a 2-week washout period, patients were crossed over to the other treatment. Symptoms were recorded daily in a diary.Twenty-one patients completed both treatment periods. Cough (p=0.02) and gastric symptoms (p=0.003) improved significantly during the omeprazole treatment in twelve patients who received placebo during the first and omeprazole during the second 8-week period. In nine patients who received omeprazole during the first 8-week period, amelioration in cough reached statistical significance only after cessation of omeprazole. Gastric symptoms also remained minor during placebo in these nine patients.Omeprazole 40 mg o.d. seems to improve chronic cough in patients with gastrooesophageal reflux and the effect of omeprazole in ameliorating both cough and reflux symptoms continues after treatment ceases. Eur Respir J 2000; 16: 633±638.

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Omeprazole for the treatment of posterior laryngitis

Cited by 180 publications

References 11 publications

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole

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