Omeprazole causes delay in gastric emptying of digestible meals

Abstract

We have studied gastric emptying of a solid, realistic meal (800 cal, 15% protein, 45% fat, 40% carbohydrate) in 21 healthy subjects twice, with and without a four-day pretreatment with 40 mg omeprazole. The last dose of the drug was taken 24 hr before the test, to avoid hypothetical nonsecretory side effects of the drug . Gastric emptying was measured by ultrasound of antral diameters. The results show that basal and maximal postprandial antral cross-sectional areas were the same during the two tests. A greater residual distention of the antrum was present throughout the study after the omeprazole treatment, the difference being significant at time 120 and 240. Omeprazole induced a highly significant delay in gastric emptying [control 199.6 (12.6) vs omeprazole 230.9 (12.7) min, mean (1 SEM); P<0.003]. The delay was not due to a prolonged lag phase, but rather to an effect on the slope of the emptying curve. This study shows that in normal subjects omeprazole delays gastric emptying of a digestible solid meal.

Prokinetic effect of gut‐oriented hypnosis on gastric emptying

“…However, we were unable to detect any influence of desensitization and/or different posture by repeatedly testing the HSs in a semirecumbent position while listening to relaxing music, compared with the basal test results. Moreover, when we developed and validated our method for measuring gastric emptying in our laboratory, no difference was found between repeated tests in the same subjects, 36 to suggests that no appreciable training effect is present. Previous studies have described an enlarged antrum in functional dyspepsia, suggesting a relationship between antral distension and symptoms.…”

“…22,42 In addition, hypnosis may modulate acid gastric secretion, 21 and omeprazole has been reported to delay gastric emptying of a solid meal. 36 We cannot rule out the possibility of an influence on gastric secretion, but no hypnotic suggestions (appearance, aroma, taste of food) specifically designed to increase acid secretion were given. Finally, there was no appreciable correlation between discomfort and fullness scores and either gastric emptying rate or maximal antral dilatation.…”

Omeprazole delays gastric emptying in healthy volunteers: an effect prevented by tegaserod

“…1 While considered generally safe, omeprazole in daily doses of 20-40 mg has been shown to significantly delay gastric emptying. [2][3][4][5] The magnitude of the delay in gastric emptying produced by omeprazole ranges from 15% to as much as 40%. 2,3 Delayed gastric emptying has been associated with adverse effects including development of dyspeptic symptoms [6][7][8] and proximal gastrointestinal (GI) tract bacterial overgrowth.…”

“…[2][3][4][5] The magnitude of the delay in gastric emptying produced by omeprazole ranges from 15% to as much as 40%. 2,3 Delayed gastric emptying has been associated with adverse effects including development of dyspeptic symptoms [6][7][8] and proximal gastrointestinal (GI) tract bacterial overgrowth. 9,10 A variable but substantial proportion of patients with symptomatic GERD who are candidates for treatment with a PPI already have delayed gastric emptying.…”

Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

“…4 However, PPIs have been known to delay gastric emptying from 15% to 40%. [5][6][7] The mechanisms for delayed gastric emptying induced by PPIs were discussed as decreased gastric acid which resulted in inadequate hydrolysis of food, enhanced secretion of gastrin, and decreased fluid secretion into the stomach. 6,8,9 Delayed gastric emptying could influence functional gastrointestinal disorders including gastroesophageal reflux disease, peptic ulcer disease and functional dyspepsia.…”