Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer

Javid, Gul; Masoodi, Ibrahim; Zargar, Showkat Ali; Khan, Bashir Ahmad; Yatoo, Ghulam Nabi; Shah, Altaf; Gulzar, Ghulam Mohammad; Sodhi, Jaswinder Singh

doi:10.1016/s0002-9343(01)00812-9

Cited by 131 publications

(128 citation statements)

References 26 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…It is also compatible with the gradual and significant decrease in the proportion of patients requiring surgical management for the control of NVUGIB seen in the literature (4,18,19).…”

Section: Discussionsupporting

confidence: 85%

“…The low rate of surgery in the management of NVUGIB in the Turkish study population indicates the success of endoscopic and medical management of the disease (18,19) reflected by a reduction in re-bleeding rates obviating the need for surgical management (20). It is also compatible with the gradual and significant decrease in the proportion of patients requiring surgical management for the control of NVUGIB seen in the literature (4,18,19).…”

Section: Discussionmentioning

confidence: 56%

See 1 more Smart Citation

An observational European study on clinical outcomes associated with current management strategies for non-variceal upper gastrointestinal bleeding (ENERGIB-Turkey)

Mungan

2012

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…It is also compatible with the gradual and significant decrease in the proportion of patients requiring surgical management for the control of NVUGIB seen in the literature (4,18,19).…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 56%

An observational European study on clinical outcomes associated with current management strategies for non-variceal upper gastrointestinal bleeding (ENERGIB-Turkey)

Mungan

2012

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…This may be due in part to poor inter-observer agreement [73,74] and variable degrees of prior irrigation [75] . Two RCTs showed that endoscopic treatment of adherent clots decreases rebleeding compared to medical therapy [68,69] , while others showed no added benefits [70][71][72] . A single RCT used high dose IV PPI bolus plus infusion, and reported no rebleeding in the acid suppression only group [70] .…”

Section: Adherent Clotmentioning

confidence: 99%

Endoscopic Management of Acute Non Variceal Upper Gastrointestinal Bleeding

Barkun

2015

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

“…This regimen resulted in a reduction of rebleeding from 22.5% to 6.7%, representing a NNT of 6 to prevent one person bleeding within 30 days. 74 Subsequent studies using lower intravenous doses of omeprazole 76 or high dose oral omeprazole [77][78][79] also demonstrated a reduction in rebleeding rate. Further study is required to determine the optimum dose, route of administration and dosing schedule of PPI in UGIB.…”

Section: Acid Suppressionmentioning

confidence: 99%

Nonvariceal Upper Gastrointestinal Bleeding

Ferguson

Mitchell²

2004

Endoscopy

View full text Add to dashboard Cite

A study in the Netherlands examined recent time trends in the incidence and outcome of upper gastrointestinal bleeding between the periods 1993-94 and 2000 [1]. The incidence of acute upper gastrointestinal bleeding decreased from 61.7 per 100 000 in 1993-94 to 47.7 per 100 000 persons annually in 2000, corresponding to a 23 % decrease in the incidence after age adjustment (95 % CI, 15 % to 30 %). Despite more frequent use of combination treatment, more frequent endoscopic interventions to treat ulcers with adherent clots, and a higher rate of protonpump inhibitor (PPI) use in the second period, the rebleeding rate (16 % vs. 15 %) and mortality rate (14 % vs. 13 %) did not differ between the two periods. Ulcer bleeding remained the most frequent cause of bleeding, at 40 % (1993-94) and 46 % (2000). Almost half of all patients with peptic ulcer bleeding were using nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin. Re-bleeding was similarly high among patients with peptic ulcer bleeding in both groups (20 % and 22 %, respectively). Increasing age, presence of severe comorbidities, and rebleeding were associated with higher mortality. An analysis of secular trends in hospitalization and mortality rates from peptic ulcer disease, upper gastrointestinal bleeding, and any gastrointestinal bleeding was published using data from the National Hospital Discharge Survey [2]. These rates were compared with sales of NSAIDs, aspirin, and acid-suppression medications from 1992 to 1999. Annual rates of hospitalization and mortality per 100 000 population for peptic ulcer disease declined from 205 to 165 and 7.7 to 6.0, respectively; the calendar year correlated negatively with both peptic ulcer disease hospitalization rates (P = 0.007) and mortality rates (P = 0.058). Sales of acid-suppression medications correlated negatively with peptic ulcer disease hospitalization rates (P = 0.037) and mortal

show abstract

Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer

Cited by 131 publications

References 26 publications

An observational European study on clinical outcomes associated with current management strategies for non-variceal upper gastrointestinal bleeding (ENERGIB-Turkey)

An observational European study on clinical outcomes associated with current management strategies for non-variceal upper gastrointestinal bleeding (ENERGIB-Turkey)

Endoscopic Management of Acute Non Variceal Upper Gastrointestinal Bleeding

Nonvariceal Upper Gastrointestinal Bleeding

Contact Info

Product

Resources

About