Omeprazole (20 mg daily) versus cimetidine (1200 mg daily) in duodenal ulcer healing and pain relief

Archambault, A; Paré, Pierre; Bailey, Robert J.; Navert, Henri; Williams, Claire; Freeman, Hugh James; Baker, S. J.; Marcon, Norman E.; Hunt, Richard H.; Sutherland, Lloyd R.; Kepkay, David L.; Saibil, Fred; Hawken, Katherine; Farley, A; Levesque, Denis; Ferguson, James M.; Westin, Jan-Ake

doi:10.1016/0016-5085(88)90003-0

Cited by 68 publications

(19 citation statements)

References 6 publications

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“…This drug is highly effective in the treatdose dependent and long-lasting inhibition of ment of gastroduodenal ulceration and reflux gastric acid secretion even after its disappearance oesophagitis (Archambault et al, 1988;Hetzel et 1. Biemond et al al., 1988;Klinkenberg-Knol et al, 1987;Lamers et al, 1984;Lauritsen et al, 1985Lauritsen et al, , 1988.…”

Section: Introductionmentioning

confidence: 99%

Effect of intermittent administration of omeprazole on serum pepsinogens in duodenal ulcer patients and healthy volunteers.

Biemond¹,

Crobach²,

Jansen³

et al. 1990

Brit J Clinical Pharma

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1. Omeprazole, a substituted benzimidazole inhibitor of the gastric H+/K(+)‐APT‐ase, was administered orally at a dose of 20 mg in the morning of 3 consecutive days, followed by a period of 4 days without medication, and this intermittent dosage regimen was continued for 4 weeks. 2. During intermittent administration of omeprazole to 10 patients with duodenal ulcer disease and 10 healthy volunteers concentrations of serum pepsinogen A and serum pepsinogen C were monitored by sensitive and specific radioimmunoassays to study whether the effect of this treatment on serum pepsinogens is different between patients and normal subjects and to evaluate whether serum pepsinogen levels can be used to assess compliance with therapy. 3. Administration of omeprazole for 3 days induced significant increases in pepsinogen A and pepsinogen C serum concentrations, which rapidly fell after stopping the omeprazole intake. The pattern of serum pepsinogens after stopping the drug was different for duodenal ulcer patients and normal subjects. Both pepsinogens were intra‐individually related in both patients and healthy subjects when compared during the first and last 3‐ day course with omeprazole, but in duodenal ulcer patients both pepsinogens tended to be higher in the last treatment course, while the opposite was found in the normal subjects. 4. The present study confirms that serum pepsinogen concentrations are higher in duodenal ulcer patients than in normal subjects, but also shows for the first time that serum pepsinogens in the patients respond differently upon stimulation with omeprazole.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 99%

Effect of intermittent administration of omeprazole on serum pepsinogens in duodenal ulcer patients and healthy volunteers.

Biemond¹,

Crobach²,

Jansen³

et al. 1990

Brit J Clinical Pharma

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“…In a Canadian study, omeprazole 20 mg and cimeridine 600 mg bid were no t statistically d ifferent in hea ling races at two and four weeks: 58 and 84% for omeprazo le and 46 and 80% for c imetidine, respectively. There appea red to be a trend in favour of o meprazole al l wo weeks, but not at four weeks (77). Recurrence after discontinuation of treatment is Lhe same as with Hz receptor antagon ists (l 14).…”

Section: Ar Present Omeprazolc Is O Nly Approved For S Hort Tenn Treamentioning

confidence: 60%

Pharmacotherapy of Peptic Ulcer Disease

Molina

Williams

1991

Canadian Journal of Gastroenterology

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of peptic ulcer disease. Can J Gastroenterol 1991 ;5( 1):21-33. The etiology of peptic ulcer is multifactorial; except for omeprazole, all drugs used for the treatment of peptic ulcer result in healing with no statistical difference at four weeks. The healing rare increases with time for active medication and placebo, and is lower among smokers than nonsmokers for all drugs but misoprostol. Mucosa[ protectives (or 'cytoprotectives') as a group seem to have a lowe r relapse rate than the Hz receptor antagonists at one year. Combination therapy h as not yet proved to be better than single drug therapy; however, the number of studies is still small, and more clinical trials are necessary. Resistant ulcers have demonstrated that acid is one of several etiological factors and that more research is needed to elucidate the reason(s) for refractoriness. The choice of therapeutic agent is generally made according to patient compliance, medication cost, side effects, effectiveness, relapse rate and physician experience with the drug. Long term maintenance therapy is effective in the prevention of ulcer relapse and is especially recommended for selected patient groups, including patients with recurrent or bleeding ulcer, patients with concomitant nonste ro idal anti-inflammatory drug use, and elderly women. Omeprazole is the treatment of choice for moderate to severe esophagitis and should be reserved for large and resistant ulcers.

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“…These studies were susceptible to the selection bias inherent in surgical cohorts 205 and furthermore they are now dated as the cohorts were completed in the 1980s before ulcer treatment was radically changed by the introduction of Helicobacter pylori eradication 206 and proton pump inhibitors. 207,208 The studies that did follow up upper gastrointestinal bleeding included only patients with proven peptic ulcers who had survived the first 30 days. (table 9.6) 9.0 *Cardiovascular definitions varied from ischaemic heart disease only to including cereberovascular disease.…”

Section: Chapter 9: Causes Of Excess Long Term Mortality: Discussionmentioning

confidence: 99%

Epidemiology of Upper Gastrointestinal Bleeding

Crooks¹,

Sung²,

Card³

2014

GI Epidemiology

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Omeprazole (20 mg daily) versus cimetidine (1200 mg daily) in duodenal ulcer healing and pain relief

Cited by 68 publications

References 6 publications

Effect of intermittent administration of omeprazole on serum pepsinogens in duodenal ulcer patients and healthy volunteers.

Effect of intermittent administration of omeprazole on serum pepsinogens in duodenal ulcer patients and healthy volunteers.

Pharmacotherapy of Peptic Ulcer Disease

Epidemiology of Upper Gastrointestinal Bleeding

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