Omentin-1 and adiponectin secretion via adipose tissue extracellular vesicles

Dracheva, K. V.; Pobozheva, I.; Анисимова, К. А.; Баландов, С. Г.; Hamid, Zarina M; Пантелеева, А. А.; Vasilevsky, Dmitrij I.; Pchelina, Sofya; Miroshnikova, V. V.

doi:10.1016/j.atherosclerosis.2021.06.436

Cited by 2 publications

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Section: Obesitymentioning

confidence: 99%

“…Importantly, major adipocytokines that are implicated in antioxidant effects, antiinflammatory activity and insulin sensitivity in the cardiovascular system and are observed to circulate at lower levels in obesity, such as omentin-1 and adiponectin [86][87][88], have been reported to be enclosed in EVs derived from WAT [89]. Omentin-1 was associated mostly with EVs from visceral AT, while adiponectin could also be found in EVs from subcutaneous AT tissue, but only for high-and medium-molecular-weight adiponectin [89]. As the reduced circulation of anti-inflammatory adipocytokines has been associated with a higher risk of cardiovascular diseases [90], further studies are warranted to determine to what extent EVs are implicated in adipocytokine protection or contribute to obesity-induced cardiac damage.…”

Section: Obesitymentioning

confidence: 99%

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Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Michel

2023

IJMS

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Adipose tissue and its diverse cell types constitute one of the largest endocrine organs. With multiple depot locations, adipose tissue plays an important regulatory role through paracrine and endocrine communication, particularly through the secretion of a wide range of bioactive molecules, such as nucleic acids, proteins, lipids or adipocytokines. Over the past several years, research has uncovered a myriad of interorgan communication signals mediated by small lipid-derived nanovesicles known as extracellular vesicles (EVs), in which secreted bioactive molecules are stably transported as cargo molecules and delivered to adjacent cells or remote organs. EVs constitute an essential part of the human adipose secretome, and there is a growing body of evidence showing the crucial implications of adipose-derived EVs in the regulation of heart function and its adaptative capacity. The adipose tissue modifications and dysfunction observed in obesity and aging tremendously affect the adipose-EV secretome, with important consequences for the myocardium. The present review presents a comprehensive analysis of the findings in this novel area of research, reports the key roles played by adipose-derived EVs in interorgan cross-talk with the heart and discusses their implications in physiological and pathological conditions affecting adipose tissue and/or the heart (pressure overload, ischemia, diabetic cardiomyopathy, etc.).

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Section: Obesitymentioning

confidence: 99%

Section: Obesitymentioning

confidence: 99%

Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Michel

2023

IJMS

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Extracellular vesicle-mediated bidirectional communication between heart and other organs

Gabisonia

Khan

Recchia

2022

American Journal of Physiology-Heart and Circulatory Physiology

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In recent years, a wealth of studies have identified various molecular species released by cardiac muscle under physiological and pathological conditions which exert local paracrine and/or remote endocrine effects. Conversely, humoral factors, principally produced by organs such as skeletal muscle, kidney or adipose tissue, may affect the function and metabolism of normal and diseased hearts. While this cross-communication within cardiac tissue and between the heart and other organs is supported by mounting evidence, research on the role of molecular mediators carried by exosomes, microvesicles and apoptotic bodies, collectively defined as extracellular vesicles (EVs), is at an early stage of investigation. Once released in the circulation, EVs can potentially reach any organ where they transfer their cargo of proteins, lipids and nucleic acids which exert potent biological effects on recipient cells. While there are a few cases where such signaling was clearly demonstrated, the results from many others studies can only be tentatively inferred based on indirect evidence obtained by infusing exogenous EVs in experimental animals or by adding them to cell cultures. This area of research is in rapid expansion and most mechanistic interpretations may change in the near future, hence the present review on the role played by EV-carried mediators in the two-way communication between heart and skeletal muscle, kidneys, bone marrow, lungs, liver, adipose tissue and brain is necessarily limited. Nonetheless, the available data are already unveiling new, intriguing and ample scenarios in cardiac physiology and pathophysiology.

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Omentin-1 and adiponectin secretion via adipose tissue extracellular vesicles

Cited by 2 publications

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Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Extracellular vesicle-mediated bidirectional communication between heart and other organs

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