Omental Fat Receptor Interacting Protein 140 mRNA Expression in Women with Polycystic Ovary Syndrome

Seow, Kok-Min; Tsai, Yieh-Loong; Juan, Chi Chang; Huang, Lee Wen; Hwang, Jiann Loung; Ho, Low Tone

doi:10.1159/000253852

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…Adipose tissue weighing about 5-6 g was obtained from omental fat tissue of all PCOS women by laparoscopy on the day of laparoscopic ovarian drilling [22]. Adipose tissue from controls was obtained during laparoscopic examination for tubal infertility or sterilization.…”

Section: Methodsmentioning

confidence: 99%

Aquaglyceroporin-7 Overexpression in Women with the Polycystic Ovary Syndrome

Seow¹,

Lin

Wang

et al. 2012

Gynecol Obstet Invest

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Background: Aquaglyceroporin-7 (AQP7) is an adipose glycerol channel protein that has been suggested to be involved in whole-body glucose homeostasis and insulin sensitivity. The aim of this study was to investigate the expression of AQP7 in visceral adipose tissues from women with the polycystic ovary syndrome (PCOS). Methods:AQP7 mRNA and protein levels were measured in omental adipose tissue from 5 women with the PCOS and 4 healthy controls matched for body mass index and age; this was done by the real-time polymerase chain reaction (PCR) and Western blotting. -Results: The women with the PCOS had significantly higher homeostasis model insulin resistance indices (HOMA_IR) and their quantitative insulin sensitivity check indices were significantly lower compared to the controls (p < 0.05). No significant difference was noted between the two groups for the plasma glycerol concentration. AQP7 mRNA expression and protein levels in omental adipose tissue from women with the PCOS were significantly higher than those of the controls (p = 0.007). AQP7 expression showed a positive correlation with fasting insulin levels, insulin levels at 2 h after glucose loading and HOMA_IR in women with the PCOS. Conclusion:AQP7 overexpression may be related to insulin sensitivity and glucose homeostasis in women with the PCOS.

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Section: Methodsmentioning

confidence: 99%

Aquaglyceroporin-7 Overexpression in Women with the Polycystic Ovary Syndrome

Seow¹,

Lin

Wang

et al. 2012

Gynecol Obstet Invest

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Role of nuclear receptor corepressor RIP140 in metabolic syndrome

Rosell

Jones

Parker

2011

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Obesity and its associated complications, which can lead to the development of metabolic syndrome, are a worldwide major public health concern especially in developed countries where they have a very high prevalence. RIP140 is a nuclear coregulator with a pivotal role in controlling lipid and glucose metabolism. Genetically manipulated mice devoid of RIP140 are lean with increased oxygen consumption and are resistant to high-fat diet-induced obesity and hepatic steatosis with improved insulin sensitivity. Moreover, white adipocytes with targeted disruption of RIP140 express genes characteristic of brown fat including CIDEA and UCP1 while skeletal muscles show a shift in fibre type composition enriched in more oxidative fibres. Thus, RIP140 is a potential therapeutic target in metabolic disorders. In this article we will review the role of RIP140 in tissues relevant to the appearance and progression of the metabolic syndrome and discuss how the manipulation of RIP140 levels or activity might represent a therapeutic approach to combat obesity and associated metabolic disorders. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.

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TA T1 Low and Intermediate Transitional Cell Carcinoma of the Bladder: Recurrence Rates and the Timing of Check Cystoscopies within the First Year

Güney

Canogullari

et al. 2008

Urol Int

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Introduction: The intensity of cystoscopic follow-up in the first year for patients with superficial bladder cancer has not been clearly defined. The cystoscopic follow-up of superficial bladder cancer accounts for a considerable workload for the urologist and is also an invasive procedure with high costs. We retrospectively reviewed our experience to determine any possible criteria which can lead to reduce the frequency of check cystoscopy. Material and Methods: A retrospective study was done on 427 patients with primary stage Ta and T1 bladder cancers treated between 1998 and 2005. The pattern of recurrence in the first year was assessed and recurrence rates calculated. Results: The recurrence rate was 22% at 3 months. The recurrence rates at 6 and 9 months were 8 and 13.6% respectively. The recurrence rate at 12 months was 9.4%. For tumors with no recurrence at 3 months, the recurrence rates at 6, 9 and 12 months were 6.6, 13.4 and 8.9% respectively. With respect to stages, there was a statistically significant difference in recurrence rate stages pTa and pT1 in the first and in the third control (p = 0.001, p = 0.003) respectively. According to the recurrence rate within the first year, the difference between G1 and G2 tumors was not statistically significant regardless of the stage (p > 0.05). Conclusions: Patients with initial stage Ta or T1 grade 1 and 2 bladder cancers and negative first cystoscopy have a significantly lower recurrence rate than those with recurrence at first cystoscopy. There is a reason to change follow-up routines but in our opinion only in patients with initial low-grade carcinoma. If the third-month cystoscopy is clear, it is appropriate to perform the first check cystoscopy 1 year after initial resection.

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Omental Fat Receptor Interacting Protein 140 mRNA Expression in Women with Polycystic Ovary Syndrome

Cited by 3 publications

References 56 publications

Aquaglyceroporin-7 Overexpression in Women with the Polycystic Ovary Syndrome

Aquaglyceroporin-7 Overexpression in Women with the Polycystic Ovary Syndrome

Role of nuclear receptor corepressor RIP140 in metabolic syndrome

TA T1 Low and Intermediate Transitional Cell Carcinoma of the Bladder: Recurrence Rates and the Timing of Check Cystoscopies within the First Year

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