Omega-3 supplement use, fish intake, and risk of non-fatal coronary artery disease and ischemic stroke in the Million Veteran Program

Ward, Rachel E.; Cho, Kelly; Nguyen, Xuan‐Mai T.; Vassy, Jason L.; Ho, Yuk‐Lam; Quaden, Rachel; Gagnon, David; Wilson, Peter W.F.; Gaziano, J. Michael; Djoussé, Luc

doi:10.1016/j.clnu.2019.03.005

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…115 However, in the US Million Veteran Program, omega-3 fatty acid supplement use was associated with 12% (95% CI, 5%–19%) lower risk of nonfatal ischemic stroke over 3.3 years of follow-up, although fish intake was not associated with stroke risk. 116 …”

Section: Stroke (Cerebrovascular Diseases)mentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

3,153

702

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BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Stroke (Cerebrovascular Diseases)mentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

3,153

702

View full text Add to dashboard Cite

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“…The article by Oomen et al [ 32 ] included three cohorts from Italy, Finland, and the Netherlands. In summary, 22 prospective cohort studies were included in the meta-analysis of CHD incidence (28,261 events and 918,783 participants) [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ], and 27 prospective cohort studies were included in the meta-analysis of CHD mortality (10,568 events and 1,139,553 participants) [ 32 , 34 , 35 , 37 , 38 , 39 , 40 , 42 , 48 , 51 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. Of these, 18 studies (16 publications) were from Europe [ 32 ...…”

Section: Resultsmentioning

confidence: 99%

“…The period of follow-up ranged from 4 to 30 years. According to the Newcastle-Ottawa scale criteria ( Tables S1 and S2 ), 25 studies (23 publications) [ 32 , 35 , 36 , 37 , 40 , 41 , 42 , 44 , 47 , 48 , 49 , 51 , 52 , 53 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 66 , 69 ] were rated as being of high quality, and 15 studies (15 publications) [ 33 , 34 , 38 , 39 , 43 , 45 , 46 , 50 , 54 , 58 , 63 , 64 , 65 , 67 , 69 ] were rated as being of medium quality.…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen prospective cohort studies [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 42 , 43 , 44 , 45 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ] were included in the dose–response analysis concerning fish consumption and CHD incidence ( Figure 4 ). The results showed that an increase in fish intake by 20 g/d is associated with a 4% [RRs = 0.96, 95% CI: (0.95, 0.97)] reduction in CHD incidence.…”

Section: Resultsmentioning

confidence: 99%

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Fish Consumption and Coronary Heart Disease: A Meta-Analysis

et al. 2020

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Epidemiological studies on the impact of fish consumption on coronary heart disease (CHD) incidence have shown inconsistent results. In addition, in terms of CHD mortality, although previous meta-analyses showed that fish consumption reduces the risk of CHD, six newly incorporated studies show that fish consumption has no impact on CHD. Therefore, the results still need to be verified. The purpose of this study is to quantitatively evaluate the impact of fish consumption on CHD incidence and mortality. Relevant studies were identified from PubMed, Web of Science, and Embase databases up to October 2019. The multivariate-adjusted relative risks (RRs) for the highest versus the lowest fish consumption categories and the 95% confidence intervals were computed with a random-effect model. A restricted cubic spline regression model was used to assess the dose–response relationship between fish consumption and CHD incidence and mortality. Forty prospective cohort studies were incorporated into research. Among them, 22 studies investigated the association between fish consumption and CHD incidence (28,261 cases and 918,783 participants), and the summary estimate showed that higher fish consumption was significantly associated with a lower CHD incidence [RR: 0.91, 95% CI: (0.84, 0.97); I2 = 47.4%]. Twenty-seven studies investigated the association between fish consumption and CHD mortality (10,568 events and 1,139,553 participants), and the summary estimate showed that higher fish intake was significantly associated with a lower CHD mortality [RR: 0.85, 95% CI: (0.77, 0.94); I2 = 51.3%]. The dose–response analysis showed that the CHD incidence and mortality were reduced by 4%, respectively, with a 20 g/day increment in fish consumption. This meta-analysis indicates that fish consumption is associated with a lower CHD incidence and mortality.

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“…Million Veteran Program). 67 The SESN1 gene, which codes for the protein sestrin, was linked with plasma lipid traits in the GWAS populations, and identified as a previously unrecognized cholesterol biosynthesis regulator in vivo. Focusing on eQTLs for pursuing the biological importance of genes has already been used to understand network features that may be important for predicting other common cardiovascular pathophenotypes, including the role of NFATC4 in type 2 diabetes mellitus.…”

Section: Linkage Methodsmentioning

confidence: 99%

Network medicine in Cardiovascular Research

Lee

Pandey

Maron

et al. 2020

Cardiovascular Research

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The ability to generate multi-omics data coupled with deeply characterizing the clinical phenotype of individual patients promises to improve understanding of complex cardiovascular pathobiology. There remains an important disconnection between the magnitude and granularity of these data and our ability to improve phenotype–genotype correlations for complex cardiovascular diseases. This shortcoming may be due to limitations associated with traditional reductionist analytical methods, which tend to emphasize a single molecular event in the pathogenesis of diseases more aptly characterized by crosstalk between overlapping molecular pathways. Network medicine is a rapidly growing discipline that considers diseases as the consequences of perturbed interactions between multiple interconnected biological components. This powerful integrative approach has enabled a number of important discoveries in complex disease mechanisms. In this review, we introduce the basic concepts of network medicine and highlight specific examples by which this approach has accelerated cardiovascular research. We also review how network medicine is well-positioned to promote rational drug design for patients with cardiovascular diseases, with particular emphasis on advancing precision medicine.

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Omega-3 supplement use, fish intake, and risk of non-fatal coronary artery disease and ischemic stroke in the Million Veteran Program

Cited by 10 publications

References 19 publications

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Fish Consumption and Coronary Heart Disease: A Meta-Analysis

Network medicine in Cardiovascular Research

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