Omega-3-polyunsatured fatty acids (O3PUFAs), compared to placebo, reduced symptoms of occupational burnout and lowered morning cortisol secretion

Jahangard, Leila; Hedayati, Mahmoud; Abbasalipourkabir, Roghayeh; Haghighi, Mohammad; Ahmadpanah, Mohammad; Faryadras, Mohammad; Mikoteit, Thorsten; Bahmani, Dena Sadeghi; Brand, Serge

doi:10.1016/j.psyneuen.2019.104384

Cited by 9 publications

(5 citation statements)

References 57 publications

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“…Regular physical exercising; 6. Current psychotherapeutic or psychopharmacological treatment, including regular intake of omega-3-polyunsaturated fatty acids [35,36].…”

Section: Participants With Burnoutmentioning

confidence: 99%

Influence of Regular Physical Activity on Mitochondrial Activity and Symptoms of Burnout—An Interventional Pilot Study

Brand

Ebner

Mikoteit

et al. 2020

JCM

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Background: Occupational burnout is both a serious public and individual health concern. Psychopharmacological and psychological interventions are often employed, while interventions involving physical activity have been less frequently studied. The aims of the present study were (1) to investigate the effects of physical activity on mitochondrial activity levels and symptoms of burnout, (2) to compare the mitochondrial activity levels and symptoms of burnout of individuals suffering burnout with those of healthy controls (HCs), and (3) to explore the associations between mitochondrial activity and burnout symptoms. Methods: Twelve males with burnout (mean age: M = 45.8 years) took part in the study. At baseline and after 12 weeks of an intervention involving physical activity, participants completed questionnaires covering symptoms of burnout and depression. In parallel, blood samples were taken to measure changes in mitochondrial functional outcomes, such as ATP levels, oxygen consumption and complex I. For comparison, baseline values of healthy controls (HCs; depression and burnout questionnaires; blood samples) were assessed. Results: Over time, symptoms of burnout (emotional exhaustion and depersonalization) and depression significantly decreased in participants with burnout (large effect sizes) but remained significantly higher than those of HCs (medium to large effect sizes). Personal accomplishment increased over time (medium effect size) but was still lower than for HCs (large effect size). At baseline and compared to HCs, individuals with burnout had significantly lower ATP levels of mitochondrial functional outcomes. Over time, mitochondrial activity levels increased among individuals with burnout. High baseline mitochondrial activity was significantly correlated with lower depression and burnout scores both at baseline and at the end of the study. Conclusions: In individuals with burnout, regular physical activity had positive effects on mitochondrial activity and on symptoms of burnout and depression. However, when compared to healthy controls, full remission was not achieved.

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“…Regular physical exercising; 6. Current psychotherapeutic or psychopharmacological treatment, including regular intake of omega-3-polyunsaturated fatty acids [35,36].…”

Section: Participants With Burnoutmentioning

confidence: 99%

Influence of Regular Physical Activity on Mitochondrial Activity and Symptoms of Burnout—An Interventional Pilot Study

Brand

Ebner

Mikoteit

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

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“…There was no indication that one of the treatments was more or less efficacious, with the exceptions of interpersonal psychotherapy (which was more effective; d = 0.20) and nondirective supportive treatment (which was less effective than the other treatments; d = −0.13) (8). New avenues to treat major depressive disorders in adults are offered such as ketamine (10), nutritional interventions such as thiamine (11), and omega-3-polyunsaturated fatty acids (12)(13)(14)(15) as well as neuromodulation (16).…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Meta-Analyses: Exercise Effects on Depression in Children and Adolescents

et al. 2020

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Background: Depression is a common threat to children and adolescents in terms of affecting psychosocial development and increasing their risk of suicide. Apart from conventional treatments for depression, physical exercise has become a promising alternative. This paper aims to systematically review the existing meta-analyses that focus on the impact of physical exercise on clinical and nonclinical depression in children and adolescents. Methods: A systematic literature search was conducted using PsycINFO, PsycARTICLES, MedLine, PubMed, and hand searching. Risk of bias analysis, effect sizes calculations, and evaluation of the methodological characteristics (AMSTAR 2) were carried out. Results: Four meta-analyses met the inclusion criteria. After analysing the overlap, the total sample contained 30 single studies (mostly including gender mixed samples) and 2,110 participants (age range 5-20 years). The medium duration of the interventions was 11.5 weeks. The sessions had a medium length of 41 min, and the frequency of implementation was three sessions per week. The most implemented intervention type was aerobic exercise, while control groups mainly continued with their regular routine, among other related options. The overall mean effect of physical exercise on depression was medium (d = −0.50). The additional analysis in clinically depressed samples documented a small to medium mean effect (d = −0.48) in favor of the intervention. Conclusion: The small to medium but consistently positive effects that were found in the present study place physical exercise as a promising and helpful alternative for children and adolescents with clinical and nonclinical depression. The limited literature focused on children and adolescents in comparison with adult samples points to the need for further research.

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“…In addition, O3PUFAs are known to have cardioprotective effects [ 219 ] and are effective at reducing depressive symptoms [ 220 ]. Daily intake of O3PUFAs also appears to have positive health effects in both female and male nurses: after O3PUFAs intake for eight consecutive weeks, both genders had lower diurnal saliva cortisol concentrations and reported diminished symptoms of occupational burnout, including reduced emotional exhaustion and increased feelings of personal accomplishment [ 221 ]. Taken together, these results suggest beneficial effects of O3PUFAs on HPA function, immune function, and regional brain activity [ 222 ].…”

Section: Individual-level Interventions To Reduce Stress and Promote ...mentioning

confidence: 99%

The Psychoneuroimmunological Model of Moral Distress and Health in Healthcare Workers: Toward Individual and System-Level Solutions

Seiler,

Milliken,

Leiter

et al. 2024

Comprehensive Psychoneuroendocrinology

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Omega-3-polyunsatured fatty acids (O3PUFAs), compared to placebo, reduced symptoms of occupational burnout and lowered morning cortisol secretion

Cited by 9 publications

References 57 publications

Influence of Regular Physical Activity on Mitochondrial Activity and Symptoms of Burnout—An Interventional Pilot Study

Influence of Regular Physical Activity on Mitochondrial Activity and Symptoms of Burnout—An Interventional Pilot Study

Systematic Review of Meta-Analyses: Exercise Effects on Depression in Children and Adolescents

The Psychoneuroimmunological Model of Moral Distress and Health in Healthcare Workers: Toward Individual and System-Level Solutions

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