Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt/Beta-Catenin Signaling

Song, Kyoungsub; Jing, Kaipeng; Kim, Jong-Seok; Yun, Eun-Jin; Shin, Soyeon; Seo, Kang-Sik; Park, Jihoon; Heo, Jun Young; Kang, Jing; Suh, Kwang Sun; Wu, Tong; Park, Jong-Il; Kweon, Gi‐Ryang; Yoon, Won‐Sang; Hwang, Byungil; Lim, Kyu

doi:10.1159/000334468

Cited by 69 publications

(43 citation statements)

References 35 publications

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“…DHA induced apoptosis in different cancers both in vitro and in vivo. 19,20 EPA supplementation reduced cell proliferation and increased apoptosis in the crypts of patients with CRC history by a selective increase in EPA uptake in the colonic mucosa. 21 When combined with RT, the pro-apoptotic effect of PUFAs was less studied.…”

Section: Early Apoptosis (%)mentioning

confidence: 98%

Interaction of ω-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines

et al. 2014

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Methods: LS174T and HT-29 cells were treated with 20 or 50 mmol/L EPA or DHA followed by single X-ray RT of 0, 2 or 4 Gy, to evaluate cell survival, apoptosis, peroxide and malondialdehyde productions. Inflammation-and apoptosis-related proteins were analyzed by Western Blot. ANOVAs were used for statistical analysis. Results: LS174T was more sensitive to RT than HT-29. DHA and to a lesser extent EPA increased cell death, apoptosis and peroxide production after RT in LS174T and to a lesser extent in HT-29 (p < 0.05). This was associated with increased expression of heat shock protein 70, decreased expression of NF-kB p65, COX-2 and Bcl-2 proteins. Conclusions: The effect of RT combination with DHA and to a lesser extent EPA was synergistic in the radio-sensitive LS174T cells, but additive in the radio-resistant HT-29 cells. This enhanced cytotoxicity was provoked at least partly by lipid peroxidation, which consequently modulated inflammatory response and induced apoptosis.

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Section: Early Apoptosis (%)mentioning

confidence: 98%

Interaction of ω-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines

et al. 2014

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“…DHA and EPA significantly inhibited cell growth and increased apoptosis in SW1990 and PANC-1 pancreatic cancer cells. DHA administration diminishes β-catenin expression and induced β-catenin/Axin/GSK-3β complex formation which is known as a precursor to β-catenin degradation [150]. In addition, when mouse pancreatic cancer cells (PANC02) were implanted into fat-1 transgenic mice, which express omega-3 FA desaturases, resulting in elevated endogenous levels of omega-3 FAs, β-catenin levels were reduced with a significant increase in apoptosis compared with control mice [150].…”

Section: Pancreatic Cancermentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

Nabavi

Bilotto

Russo

et al. 2015

Cancer Metastasis Rev

128

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Over the past decades, extensive studies have addressed the therapeutic effects of omega-3 polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as cardiovascular and neurodegenerative diseases, cancer, etc. A growing body of scientific research shows the pharmacokinetic information and safety of these natural occurring substances. Moreover, during recent years, a plethora of studies has demonstrated that omega-3 FAs possess therapeutic role against certain types of cancer. It is also known that omega-3 FAs can improve efficacy and tolerability of chemotherapy. Previous reports showed that suppression of nuclear factor-κB, activation of AMPK/SIRT1, modulation of cyclooxygenase (COX) activity, and up-regulation of novel anti-inflammatory lipid mediators such as protectins, maresins, and resolvins, are the main mechanisms of antineoplastic effect of omega-3 FAs. In this review, we have collected the available clinical data on the therapeutic role of omega-3 FAs against breast cancer, colorectal cancer, leukemia, gastric cancer, pancreatic cancer, esophageal cancer, prostate cancer, lung cancer, head and neck cancer, as well as cancer cachexia. We also discussed the chemistry, dietary source, and bioavailability of omega-3 FAs, and the potential molecular mechanisms of anticancer and adverse effects.

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“…The story is far from clear, though. Multiple studies show that fatty acids, including palmitate 31 and omega-3 polyunsaturated fatty acid 32 , decrease Wnt/β-catenin signaling in various stem cell populations. In particular, stearic and palmitic acid inhibit Wnt signaling by binding to the Wnt inhibitor factor 1 33 .…”

Section: Intestinal Epithelial Cell Proliferation and Differentiationmentioning

confidence: 99%

Nutrient-induced intestinal adaption and its effect in obesity

Dailey

2014

Physiology & Behavior

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Obese and lean individuals respond differently to nutrients with changes in digestion, absorption and hormone release. This may be a result of differences in intestinal epithelial morphology and function driven by the hyperphagia or the type of diet associated with obesity. It is well known that the maintenance and growth of the intestine is driven by the amount of luminal nutrients, with high nutrient content resulting in increases in cell number, villi length and crypt depth. In addition, the type of nutrient appears to contribute to alterations in the morphology and function of the epithelial cells. This intestinal adaptation may be what is driving the differences in nutrient processing in lean versus obese individuals. This review describes how nutrients may be able to induce changes in intestinal epithelial cell proliferation, differentiation and function and the link between intestinal adaptation and obesity.

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Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt/Beta-Catenin Signaling

Cited by 69 publications

References 35 publications

Interaction of ω-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines

Interaction of ω-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

Nutrient-induced intestinal adaption and its effect in obesity

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