Omega-3 polyunsaturated fatty acids reduce vascular tone and inflammation in human saphenous vein

Daci, Armond; Özen, Gülsev; Uyar, İmran; Civelek, Erkan; Yildirim, F. İlkay Alp; Durman, Deniz Kaleli; Teskìn, Önder; Norel, Xavier; Uydeş-Doğan, B. Sönmez; Topal, Gökçe

doi:10.1016/j.prostaglandins.2017.08.007

Cited by 11 publications

(5 citation statements)

References 60 publications

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“…A beneficial effect of omega-3 PUFAs on the peripheral vein reactivity has been observed ex vivo using human saphenous veins, as indicated by the fact that an 18-h treatment of rings with EPA and DHA (100 µM each) reduced their contractile response to noradrenaline in normal veins [46]. In addition, such a pretreatment with EPA and DHA reduced the generation of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in varicose veins, which are associated with pro-inflammatory conditions [46].…”

Section: Discussionmentioning

confidence: 96%

Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases

Gærtner

Auger

Farooq

et al. 2020

IJMS

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In humans, aging is associated with endothelial dysfunction and an increased risk of venous thromboembolism. Although intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) at a ratio of 6:1 by old rats improved the endothelial dysfunction in arteries, the impact on veins remains unclear. Eight-month-old male Wistar rats were either untreated or orally administered corn oil, EPA:DHA 1:1, or EPA:DHA 6:1 (500 mg/kg/d) for seven days. Vascular reactivity was studied by myography. In middle-aged femoral artery rings, acetylcholine caused a partial relaxation at low concentrations and a contractile response at high concentrations, whereas in the old femoral vein only a partial relaxation was observed. The EPA:DHA 6:1 treatment blunted the contractile response to acetylcholine in the middle-aged femoral artery and both EPA:DHA 6:1 and 1:1 increased the relaxation to acetylcholine in the old femoral vein. No such effects were observed with corn oil. Both the non-selective cyclooxygenase inhibitor indomethacin and the COX-1 inhibitor SC-560 increased the relaxation to acetylcholine in the middle-aged femoral artery whereas the COX-2 inhibitor NS-398 increased that in the middle-aged femoral vein. In conclusion, our results indicate that aging is associated with an endothelial dysfunction in the femoral artery and vein, which can be improved by EPA:DHA 6:1 treatment—most likely via a cyclooxygenase-dependent mechanism.

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Section: Discussionmentioning

confidence: 96%

Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases

Gærtner

Auger

Farooq

et al. 2020

IJMS

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“…In addition to this omega 3 polyunsaturated fatty acids were shown to be beneficial in inflammation and contractility in SV tissues [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacotherapy Evaluation and Utilization in Coronary Artery Bypass Grafting Patients in Kosovo during the Period 2016-2017

Daci¹,

Bozalija²,

Cavolli³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Coronary Artery Bypass Grafting (CABG) is realised in patients with critical or advanced disease of coronary arteries. There are different pharmacotherapeutic approaches which are used as management, treatment and preventive therapy in cardiovascular disease or related comorbidities. Performing a successful surgery, pharmacotherapy, and increase of bypass patency rate remains a serious challenge.AIM:This study aims to analyse the patient characteristics undergoing CABG and evaluation of their drug utilisation rate and daily dosages in the perioperative period.MATERIAL AND METHODS:Data were collected from 102 patients in the period 2016-2017 and detailed therapeutic prescription and dosages, patient characteristics were analysed before the operation, after the operation and visit after operation in the Clinic of Cardiac surgery-University Clinical Center of Kosovo.RESULTS:Our findings had shown that patients provided to have normal biochemical parameters in the clinic before the operation, and were related to cardiovascular diseases and comorbidities and risk factors with mainly elective intervention. The, however, higher utilisation of cardiovascular drugs such as beta blockers, diuretics, anticoagulants, statins and lower calcium blockers, ACEi, ARBs, hydrochlorothiazide, amiodarone were founded. ARBs, beta blockers, statins, nitrates and nadroparin utilisation decreased after operation and visit after the operation, whereas amiodarone only in the visit after the operation. Diuretics are increased after the operation which decreases in the visit after the operation. Regarding the daily dosage, only metoprolol was increased in the visit after operation (P < 0.001) and visit after operation (P < 0.05) whereas losartan and furosemide were increased (P < 0.01) and (P < 0.05) respectively.CONCLUSION:The study showed that beta blockers, statins, aspirin, nitrates (before the operation), furosemide and spironolactone are the most utilised drugs. However, we found low utilisation rate for ACEi, ARBs, clopidogrel, nadroparin, warfarin, xanthines, amiodarone, calcium blockers. Daily dosages were different compared to before CABG only in metoprolol, losartan, and furosemide.

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“…Clinical studies have repeatedly suggested an association of ω-3 PUFA intake with decreased vascular resistance [106,107] and mechanisms underlying this association were extensively investigated in human and animal studies [108,109]. Although some studies failed to demonstrate improved vascular reactivity with the use of ω-3 PUFAs [110][111][112], a large body of evidence supports the view that these compounds could improve both endothelium-dependent and endothelium-independent peripheral vascular responses.…”

Section: ω-3 Pufas and Regulation Of Peripheral Vascular Resistancementioning

confidence: 99%

Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?

Brosolo,

Da Porto,

Marcante

et al. 2023

IJMS

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Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including alpha-linolenic acid (ALA) and its derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are “essential” fatty acids mainly obtained from diet sources comprising plant oils, marine blue fish, and commercially available fish oil supplements. Many epidemiological and retrospective studies suggested that ω-3 PUFA consumption decreases the risk of cardiovascular disease, but results of early intervention trials have not consistently confirmed this effect. In recent years, some large-scale randomized controlled trials have shed new light on the potential role of ω-3 PUFAs, particularly high-dose EPA-only formulations, in cardiovascular prevention, making them an attractive tool for the treatment of “residual” cardiovascular risk. ω-3 PUFAs' beneficial effects on cardiovascular outcomes go far beyond the reduction in triglyceride levels and are thought to be mediated by their broadly documented “pleiotropic” actions, most of which are directed to vascular protection. A considerable number of clinical studies and meta-analyses suggest the beneficial effects of ω-3 PUFAs in the regulation of blood pressure in hypertensive and normotensive subjects. These effects occur mostly through regulation of the vascular tone that could be mediated by both endothelium-dependent and independent mechanisms. In this narrative review, we summarize the results of both experimental and clinical studies that evaluated the effect of ω-3 PUFAs on blood pressure, highlighting the mechanisms of their action on the vascular system and their possible impact on hypertension, hypertension-related vascular damage, and, ultimately, cardiovascular outcomes.

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Omega-3 polyunsaturated fatty acids reduce vascular tone and inflammation in human saphenous vein

Cited by 11 publications

References 60 publications

Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases

Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases

Pharmacotherapy Evaluation and Utilization in Coronary Artery Bypass Grafting Patients in Kosovo during the Period 2016-2017

Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?

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