Omega-3 Polyunsaturated Fatty Acids Inhibited Tumor Growth via Preventing the Decrease of Genomic DNA Methylation in Colorectal Cancer Rats

Huang, Qionglin; Wen, Jinhua; Chen, Guangzhao; Ge, Miaomiao; Gao, Yongping; Ye, Xiaoxia; Chun-an, Liu; Cai, Chun

doi:10.1080/01635581.2016.1115526

Cited by 33 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study to explore whether n-3 PUFA affects DNA methylation levels in colorectal cancer, rats were fed with n-3 PUFA during tumor induction [23]. The main results showed that the tumor incidence in rats fed the n-3 PUFA-enriched diet was lower than in the non-treated group, demonstrating that the anti-tumorigenic effect of n-3 PUFA was mediated by an increase of DNA methylation [23]. On the other hand, Shen et al observed that n-3 PUFA could modulate histone modifications by inhibiting enzymes that catalyze or alter the availability of substrates that are required for enzymatic reactions.…”

Section: Resultsmentioning

confidence: 99%

Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

et al. 2019

View full text Add to dashboard Cite

Background Chronic illnesses like obesity, type 2 diabetes (T2D) and cardiovascular diseases, are worldwide major causes of morbidity and mortality. These pathological conditions involve interactions between environmental, genetic, and epigenetic factors. Recent advances in nutriepigenomics are contributing to clarify the role of some nutritional factors, including dietary fatty acids in gene expression regulation. This systematic review assesses currently available information concerning the role of the different fatty acids on epigenetic mechanisms that affect the development of chronic diseases or induce protective effects on metabolic alterations. Methods A targeted search was conducted in the PubMed/Medline databases using the keywords “fatty acids and epigenetic”. The data were analyzed according to the PRISMA-P guidelines. Results Consumption fatty acids like n-3 PUFA: EPA and DHA, and MUFA: oleic and palmitoleic acid was associated with an improvement of metabolic alterations. On the other hand, fatty acids that have been associated with the presence or development of obesity, T2D, pro-inflammatory profile, atherosclerosis and IR were n-6 PUFA, saturated fatty acids (stearic and palmitic), and trans fatty acids (elaidic), have been also linked with epigenetic changes. Conclusions Fatty acids can regulate gene expression by modifying epigenetic mechanisms and consequently result in positive or negative impacts on metabolic outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The implication of fatty acids on the methylome landmark is well-known but the mechanism behind this effect and their targets are still under study (see Burdge and Lillycrop, 2014 for review). Recent studies have started to elucidate this mechanism, correlating the addition of PUFA and changes over the DNA methyltransferase expression patterns (Huang et al, 2016). Thus, in some cases the dietary input of fatty acids finally acts, trough methylation mechanism, over the regulator regions of clue genes in the metabolic homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic DNA Methylation Mediating Octopus vulgaris Early Development: Effect of Essential Fatty Acids Enriched Diet

et al. 2017

View full text Add to dashboard Cite

The common octopus, Octopus vulgaris, is a good candidate for aquaculture but a sustainable production is still unviable due to an almost total mortality during the paralarvae stage. DNA methylation regulates gene expression in the eukaryotic genome, and has been shown to exhibit plasticity throughout O. vulgaris life cycle, changing profiles from paralarvae to adult stages. This pattern of methylation could be sensitive to small alterations in nutritional and environmental conditions during the species early development, thus impacting on its health, growth and survival. In this sense, a full understanding of the epigenetic mechanisms operating during O. vulgaris development would contribute to optimizing the culture conditions for this species. Paralarvae of O. vulgaris were cultured over 28 days post-hatching (dph) using two different Artemia sp. based diets: control and a long chain polyunsaturated fatty acids (LC-PUFA) enriched diet. The effect of the diets on the paralarvae DNA global methylation was analyzed by Methyl-Sensitive Amplification Polymorphism (MSAP) and global 5-methylcytosine enzyme-linked immunosorbent assay (ELISA) approaches. The analysis of different methylation states over the time revealed a global demethylation phenomena occurring along O. vulgaris early development being directly driven by the age of the paralarvae. A gradual decline in methylated loci (hemimethylated, internal cytosine methylated, and hypermethylated) parallel to a progressive gain in non-methylated (NMT) loci toward the later sampling points was verified regardless of the diet provided and demonstrate a pre-established and well-defined demethylation program during its early development, involving a 20% of the MSAP loci. In addition, a differential behavior between diets was also observed at 20 dph, with a LC-PUFA supplementation effect over the methylation profiles. The present results show significant differences on the paralarvae methylation profiles during its development and a diet effect on these changes. It is characterized by a process of demethylation of the genome at the paralarvae stage and the influence of diet to favor this methylation loss.

show abstract

“…The human diet is commonly deficient in ω3-fatty acids that are common components of fish and fish products. Fish oil, high in ω3-fatty acids, is known to have anticancer activities through apoptosis of cancer cells, and numerous reports have appeared to support this claim [1][2][3][4][5][6][7][8]. Thus, docosahexaenoic (22:6, n-3) and eicosapentaenoic (20:5, n-3) acids are effective antitumor adjuvants that provoke apoptosis in several types of tumor cells without an injury to natural cells [9][10][11].…”

Section: Fatty Acidsmentioning

confidence: 99%

Short-Chain Fatty Acids Are Antineoplastic Agents

Abaza¹,

Afzal²,

Afzal³

2017

Fatty Acids

View full text Add to dashboard Cite

Human diet contains a mixture of saturated and unsaturated fatty acids. These are either long, medium or short chain fatty acids. As commonly believed, all fatty acids are not detrimental to human health. In addition to energy reserves, long chain fatty acids are known as acylating agents for many biomolecules such as cholesterol, terpenoids as well as steroid hormones. They are also involved in acylation of polyphenols such as flavonoids making them palatable for better absorption and biological activities. Polyunsaturated fatty acids (PUFAs) are known for their numerous beneficial health effects including cancer and inflammation. PUFA, particularly ω3 fatty acids, have attracted attention as anticancer agents and particularly for colorectal cancer. PUFAs exhibit immunomodulatory activities controlling inflammosome and are used as adjuvants together with standard anticancer drugs. A reciprocal interaction of short chain fatty acids with PUFAs has been suggested for their anticancer activities. Thus, in colon cancer cells, sodium butyrate (NaB) interacts with docosahexaenoic acid inducing cell differentiation or catalyze apoptosis. These results encouraged us to investigate NaB, a C4 acid, as an adjuvant to standard proteasome inhibitors. Our results show that NaB sensitizes colon cancer cell lines for treatment with proteasome inhibitors.

show abstract

Omega-3 Polyunsaturated Fatty Acids Inhibited Tumor Growth via Preventing the Decrease of Genomic DNA Methylation in Colorectal Cancer Rats

Cited by 33 publications

References 32 publications

Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

Epigenetic DNA Methylation Mediating Octopus vulgaris Early Development: Effect of Essential Fatty Acids Enriched Diet

Short-Chain Fatty Acids Are Antineoplastic Agents

Contact Info

Product

Resources

About