Omega-3 polyunsaturated fatty acids and anxiety disorders

Ross, Brian M.

doi:10.1016/j.plefa.2009.10.004

Cited by 64 publications

(43 citation statements)

References 51 publications

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“…Unlike the present analysis, the results of these studies suggest that increased MUFA are associated with decreased risk of depression (19,40) . While these studies were not directly measuring anxiety, it is thought that depression and anxiety are mechanistically related (17) and this justified the current investigation.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, a population-based study of 2416 New Zealand adults that measured EPA and DHA in serum phospholipids found inconsistent associations between the LC n-3 FA and mental well-being measured using the Short Form Health Survey questionnaire (SF-36) (16) . There has been far less focus on anxiety than depression in relation to n-3 FA intakes in the research literature, despite the probability that mood and anxiety disorders are mechanistically related (17) . One prospective cohort study of 7903 university graduates showed that dietary n-3 fat intake provided a potential benefit to total mental disorders (anxiety, depression, stress) at baseline (18) .…”

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confidence: 99%

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Unsaturated fat intakes and mental health outcomes in young women from the Australian Longitudinal Study on Women’s Heath

Daley

Patterson

Sibbritt

et al. 2014

Public Health Nutr.

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Results: Adjusted logistic regression analyses found statistically significant associations between higher intakes of α-linolenic acid and decreased likelihood of depressive symptoms indicated by the ten-item Center for Epidemiological Studies Depression Scale (CESD-10; OR = 0·77; 95 % CI 0·60, 0·99; P = 0·040) and the Short Form Health Survey (SF-36) mental health subscale (OR = 0·73 95 % CI 0·56, 0·96; P = 0·024). Furthermore, higher intakes of n-6 fatty acids (OR = 0·96, 95 % CI 0·93, 0·99; P = 0·019) and linoleic acid (OR = 0·96, 95 % CI 0·93, 0·99; P = 0·020) were associated with decreased likelihood of self-reported diagnosed anxiety and higher intakes of n-9 fatty acids (OR = 1·02, 95 % CI 1·00, 1·04; P = 0·041) and oleic acid (OR = 1·02, 95 % CI 1·00, 1·05; P = 0·046) were associated with increased likelihood of self-reported diagnosed anxiety. Conclusions:: Increased intakes of α-linolenic acid were associated with a reduced likelihood of depressive symptoms, increased intakes of n-6 fatty acids and linoleic acid were associated with a reduced likelihood of self-reported anxiety, and increased intakes of n-9 fatty acids and oleic acid were associated with an increased likelihood of anxiety. Additional studies are needed to further elucidate associations between unsaturated fatty acids and depression and anxiety.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Unsaturated fat intakes and mental health outcomes in young women from the Australian Longitudinal Study on Women’s Heath

Daley

Patterson

Sibbritt

et al. 2014

Public Health Nutr.

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“…Omega-3 PUFAs and fish oil, the major dietary source of Omega-3 PUFA have been extensively studied as dietary supplements suggesting beneficial effects for the treatment of inflammation [67][68][69], macular degeneration [70,71], AD [72][73][74][75] depression [76] anxiety disorders [77], and psychotic disorders [78]. Optimum maintenance of the synaptosome, brain cell functions, and general health of human CNS are potentially facilitated by Omega-3 PUFA [79][80][81].…”

Section: Aarti and Priyankamentioning

confidence: 99%

Review on Therapeutic Effects Mediated by Omega-3 Fatty Acids in Alzheimer’s Disease

Sati

Bhatt²

2018

Asian J Pharm Clin Res

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Alzheimer's disease (AD) is a neurodegenerative disorder with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the Omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), and accordingly, administration of DHA has been proposed as a possible treatment for this pathology. DHA and its derivatives like 2-hydroxy DHA-(OHDHA) have a strong therapeutic potential to treat AD. Studies have demonstrated that DHA induced lipid modifications are paralleled with a reduction in amyloid-beta (Αβ) accumulation and full recovery of cognitive impairment. Omega-3 fatty acids also caused alterations in the subcellular distribution of secretases and reduced Αβ-induced tau protein phosphorylation as well. Furthermore, OHDHA enhanced the survival of neuron-like differentiated cells exposed to different insults such as oligomeric Αβ and N-methyl-D-aspartate-mediated neurotoxicity. In conclusion, this review focuses on the pleiotropic effects of Omega-3 fatty acids that might prove beneficial to treat AD.

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“…For instance, research indicates a beneficial influence of omega-3 PUFAs on depressive symptoms in individuals with major depressive disorder, although the relationship is far from understood (Giles et al, 2013;Lin et al, 2010;Martins, 2009;Parker et al, 2006;Sinclair et al, 2007). Omega-3 PUFAs may also benefit individuals with bipolar disorder (Turnbull et al, 2008), anxiety disorders (Ross, 2009) and attention deficit hyperactivity disorder (Frensham et al, 2012).…”

Section: Introductionmentioning

confidence: 99%