Omega-3 microbial oils from marine thraustochytrids as a sustainable and technological solution: A review and patent landscape

Colonia, Brigitte Sthepani Orozco; Pereira, Gilberto Vinícius de Melo; Soccol, Carlos Ricardo

doi:10.1016/j.tifs.2020.03.007

Cited by 39 publications

(26 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are important components of mangrove forest microbial ecosystems, recycling marine nutrients into a broad variety of biomolecules used as nutrients for both marine and terrestrial species. Thraustochytrids have been extensively studied over the last decade because of their biotechnological applications in human health based on their ability to produce very long chains of polyunsaturated fatty acids (VLC-PUFAs), mainly ω3-docosahexaenoic acid (DHA, C22:6) [13][14][15]. Health benefits of DHA include anti-inflammatory properties, cardiovascular protection, proper development of neural tissues and decreased risks of depression, Alzheimer's, and Parkinson's diseases [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics of Protein Isolated from Thraustochytrid Oilcake

Tran

Miranda

Mouradov

et al. 2020

Foods

View full text Add to dashboard Cite

The oil from thraustochytrids, unicellular heterotrophic marine protists, is increasingly used in the food and biotechnological industries as it is rich in omega-3 fatty acids, squalene and a broad spectrum of carotenoids. This study showed that the oilcake, a by-product of oil extraction, is equally valuable as it contained 38% protein/dry mass, and thraustochytrid protein isolate can be obtained with 92% protein content and recovered with 70% efficiency. The highest and lowest solubilities of proteins were observed at pH 12.0 and 4.0, respectively, the latter being its isoelectric point. Aspartic acid, glutamic acid, histidine, and arginine were the most abundant amino acids in proteins. The arginine-to-lysine ratio was higher than one, which is desired in heart-healthy foods. The denaturation temperature of proteins ranged from 167.8–174.5 °C, indicating its high thermal stability. Proteins also showed high emulsion activity (784.1 m2/g) and emulsion stability (209.9 min) indices. The extracted omega-3-rich oil melted in the range of 30–34.6 °C and remained stable up to 163–213 °C. This study shows that thraustochytrids are not only a valuable source of omega 3-, squalene- and carotenoid-containing oils, but are also rich in high-value protein with characteristics similar to those from oilseeds.

show abstract

Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics of Protein Isolated from Thraustochytrid Oilcake

Tran

Miranda

Mouradov

et al. 2020

Foods

View full text Add to dashboard Cite

show abstract

“…has been designated safe for human and for animal consumption by the United States Food and Drug Administration (US FDA 7 ). Thus, it is not surprising that 731 patents on thraustochytrids were published between 1999 and 2018 (US and Eurasia are top in the list), with most patents targeting the use of their chemicals for human well-being purposes, especially the use of ω-3 oils (Colonia et al, 2020).…”

Section: Thraustochytridsmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

View full text Add to dashboard Cite

Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

show abstract

“…Mono-and diglycerides have not been reported as a major metabolite of marine microorganisms. However, there are several prolific producers of polyunsaturated oils among marine microorganisms, including microalgae and protists (thraustochytrids) [144,145]. This does offer the opportunity to use marine microbial oils as a feedstock for the production of mono-and di-glycerides through controlled glycerolysis [146].…”

Section: Food Applicationsmentioning

confidence: 99%

Marine-Derived Surface Active Agents: Health-Promoting Properties and Blue Biotechnology-Based Applications

et al. 2020

View full text Add to dashboard Cite

Surface active agents are characterized for their capacity to adsorb to fluid and solid-water interfaces. They can be classified as surfactants and emulsifiers based on their molecular weight (MW) and properties. Over the years, the chemical surfactant industry has been rapidly increasing to meet consumer demands. Consequently, such a boost has led to the search for more sustainable and biodegradable alternatives, as chemical surfactants are non-biodegradable, thus causing an adverse effect on the environment. To these ends, many microbial and/or marine-derived molecules have been shown to possess various biological properties that could allow manufacturers to make additional health-promoting claims for their products. Our aim, in this review article, is to provide up to date information of critical health-promoting properties of these molecules and their use in blue-based biotechnology (i.e., biotechnology using aquatic organisms) with a focus on food, cosmetic and pharmaceutical/biomedical applications.

show abstract

Omega-3 microbial oils from marine thraustochytrids as a sustainable and technological solution: A review and patent landscape

Cited by 39 publications

References 88 publications

Physicochemical Characteristics of Protein Isolated from Thraustochytrid Oilcake

Physicochemical Characteristics of Protein Isolated from Thraustochytrid Oilcake

The Essentials of Marine Biotechnology

Marine-Derived Surface Active Agents: Health-Promoting Properties and Blue Biotechnology-Based Applications

Contact Info

Product

Resources

About