Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials

Heshmati, Javad; Morvaridzadeh, Mojgan; Maroufizadeh, Saman; Akbari, Abolfazl; Yavari, Mahsa; Amirinejad, Ali; Maleki‐Hajiagha, Arezoo; Sepidarkish, Mahdi

doi:10.1016/j.phrs.2019.104462

Cited by 120 publications

(80 citation statements)

References 71 publications

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“…Our results also show that treatment with the oil mixture reduces the expression of pro-oxidant and inflammatory markers in the liver and increases the mRNA levels of antioxidant enzymes, such as GSR and SOD-1. These data are in accordance with a meta-analysis of clinical trials, which shows that omega-3 fatty acid supplementation improves the serum levels of the antioxidant enzyme GPx, and reduces the concentrations of the oxidative marker malondialdehyde [ 54 ]. It has been proposed that these antioxidant effects are mediated by basal release of nitric oxide and inhibition of NF-κB signaling [ 55 ].…”

Section: Discussionsupporting

confidence: 88%

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

et al. 2020

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Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase in life expectancy, there is a strong interest in the search for anti-aging strategies to treat and prevent these aging-induced disorders. Both omega 3 polyunsaturated fatty acids (ω-3 PUFA) and extra virgin olive oil (EVOO) exert numerous metabolic and cardiovascular benefits in the elderly. In addition, EVOO constitutes an interesting ingredient to stabilize ω-3 PUFA and decrease their oxidation process due to its high content in antioxidant compounds. ω-3 PUFA are commonly obtained from fish. However, more ecological and sustainable sources, such as algae oil (AO) can also be used. In this study, we aimed to study the possible beneficial effect of an oil mixture composed by EVOO (75%) and AO (25%) rich in ω-3 PUFA (35% docosahexaenoic acid (DHA) and 20% eicosapentaenoic acid (EPA)) on the cardiometabolic alterations associated with aging. For this purpose; young (three months old) and old (24 months old) male Wistar rats were treated with vehicle or with the oil mixture (2.5 mL/kg) for 21 days. Treatment with the oil mixture prevented the aging-induced increase in the serum levels of saturated fatty acids (SFA) and the aging-induced decrease in the serum concentrations of mono-unsaturated fatty acids (MUFA). Old treated rats showed increased serum concentrations of EPA and DHA and decreased HOMA-IR index and circulating levels of total cholesterol, insulin and IL-6. Treatment with the oil mixture increased the mRNA levels of antioxidant and insulin sensitivity-related enzymes, as well as reduced the gene expression of pro-inflammatory markers in the liver and in cardiac and aortic tissues. In addition, the treatment also prevented the aging-induced endothelial dysfunction and vascular insulin resistance through activation of the PI3K/Akt pathway. Moreover, aortic rings from old rats treated with the oil mixture showed a decreased response to the vasoconstrictor AngII. In conclusion, treatment with a mixture of EVOO and AO improves the lipid profile, insulin sensitivity and vascular function in aged rats and decreases aging-induced inflammation and oxidative stress in the liver, and in the cardiovascular system. Thus, it could be an interesting strategy to deal with cardiometabolic alterations associated with aging.

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Section: Discussionsupporting

confidence: 88%

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

et al. 2020

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“…This result is similar to the report of Mohebbati et al that showed N. sativa reduced tissue MDA level but increased total thiol and SOD activity in the kidney tissue (Mohebbati et al, 2016). Kascurlu et al indicated that treatment of renal reperfusion injury with N. sativa reduced the elevated tissue MDA levels and increased activities of the enzymatic antioxidants glutathione peroxidase and catalase (Caskurlu et al, 2016) but in a study by Namazi et al reported that N. sativa oil along with a lowcalorie diet not had significant changes in lipid peroxidation, glutathione peroxidase, and total antioxidant capacity concentrations, while decreased weight and increased SOD levels in obese women (Namazi, Mahdavi, Alizadeh, & Farajnia, 2015 therefore, it can be effective in reducing MDA (Heshmati et al, 2018;Heshmati et al, 2019;Sepidarkish et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus

Kooshki

Tofighiyan

Rastgoo

et al. 2020

Phytotherapy Research

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This study aimed to evaluate the effects of Nigella sativa oil on serum level of systemic inflammation, oxidative stress, fasting blood glucose (FBG), and lipid profile in patients with type 2 diabetes mellitus (T2DM). This double-blind randomized clinical trial study was based on 50 patients with T2DM. Patients were allocated randomly to either N. sativa oil or placebo groups. The intervention group received 1,000 mg N. sativa oil as two capsules, daily for 8 weeks, whereas the placebo group received a corresponding placebo. At baseline and the end of the study, 5 ml blood was collected from each patient after 14-hour fasting for measuring serum C-reactive protein (hs-CRP), malondialdehyde (MDA), FBS, and lipid profile. Analyses covariance was performed to compare investigated parameters between two groups, controlled for relevant covariates. Using N. sativa supplement was significantly associated with decrease in FBS (p < .001), triglyceride (p < .001), total cholesterol (p < .001), low-density lipoprotein cholesterol (p < .001), serum hs-CRP, MDA (p < .001) and increase in serum level of high-density lipoprotein cholesterol (p < .001) in intervention group compared with placebo group. Nigella sativa oil supplement has cardiovascular protective effects in patients with T2DM, by improving the lipid profile and glycemia, by reducing the C-reactive protein level and the lipid peroxidation.

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“…The omega-3 FAs supplementation can be an enhancer factor in the antioxidant defence against ROS [142] and has been demonstrated to be effective against oxidative stress in the treatment of ADHD. A pilot study demonstrated that supplementation with alpha-linolenic acid, an omega-3 FAs, improved ADHD symptoms [91].…”

Section: Omega-3 Fatty Acids Exert Antioxidant Activitymentioning

confidence: 99%

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

et al. 2020

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Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

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Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials

Cited by 120 publications

References 71 publications

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

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